A well-defined block copolymer serving as surfactants in separation of 1,4-dihydropyridines by open-tubular capillary eletrochromatography
文献类型：期刊论文
| 作者 | Li, Yaping1,2; Qi, Li1; Qiao, Juan1; Shen, Ying1,2; Yan, Huijuan3; Xin, Peiyong1,2; Ma, Huimin1 |
| 刊名 | ELECTROPHORESIS
 |
| 出版日期 | 2012-07-01 |
| 卷号 | 33期号:13页码:2019-2027 |
| 关键词 | Covalent Coating Diblock Copolymer Ot-cec Self-assembly |
| ISSN号 | 0173-0835 |
| DOI | 10.1002/elps.201100548 |
| 英文摘要 | A novel series of diblock copolymers, poly(butyl methacrylate)n-block-poly(glycidyl methacrylate)m [P(BMA)n-b-P(GMA)m], were synthesized by atom transfer radical polymerization and developed as covalent coating of capillaries. The excellent performance of this coating in separation of three 1,4-dihydropyridines (DHPs) derivatives (amlodipine, nicardipine, nitrendipine) was achieved when the diblock copolymers self-assembled into micelles, which was confirmed by transmission electron microscopy, dynamic light scattering, and atom force microscopy. Meanwhile, the effects of block ratio n/m, pH value, buffer concentration, and organic solvents on the separation of 1,4-DHPs were investigated in detail. Then, the relationship between the morphologies of copolymers and the separation resolutions of 1,4-DHPs was discussed. Furthermore, the proposed method exhibited good run-to-run and column-to-column precision with relative standard deviations of electroosmotic flow less than 3.0%. It was also validated with linearity of three 1,4-DHPs in the range of 0.011.80 mM (r2 = 99.7%), efficient recovery (94103%), and good repeatability (= 3.8%). In addition, three 1,4-DHPs were successfully separated in the spiked human serum sample, which indicated the potential utility of this method in biological sample analysis. |
| 语种 | 英语 |
| WOS记录号 | WOS:000306404700014 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49427]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Qi, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yaping,Qi, Li,Qiao, Juan,et al. A well-defined block copolymer serving as surfactants in separation of 1,4-dihydropyridines by open-tubular capillary eletrochromatography[J]. ELECTROPHORESIS,2012,33(13):2019-2027. |
| APA | Li, Yaping.,Qi, Li.,Qiao, Juan.,Shen, Ying.,Yan, Huijuan.,...&Ma, Huimin.(2012).A well-defined block copolymer serving as surfactants in separation of 1,4-dihydropyridines by open-tubular capillary eletrochromatography.ELECTROPHORESIS,33(13),2019-2027. |
| MLA | Li, Yaping,et al."A well-defined block copolymer serving as surfactants in separation of 1,4-dihydropyridines by open-tubular capillary eletrochromatography".ELECTROPHORESIS 33.13(2012):2019-2027. |
入库方式： OAI收割
来源：化学研究所
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