The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy
文献类型：期刊论文
| 作者 | Xiao, Haihua1,2; Song, Haiqin3; Zhang, Yu4; Qi, Ruogu1,2; Wang, Rui1,2; Xie, Zhigang1; Huang, Yubin1; Li, Yuxin4; Wu, Yin5; Jing, Xiabin1 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2012-11-01 |
| 卷号 | 33期号:33页码:8657-8669 |
| ISSN号 | 0142-9612 |
| 关键词 | Amphiphilic Copolymer Drug Delivery Systems Micelles Multinuclear Platinum Drugs |
| DOI | 10.1016/j.biomaterials.2012.08.015 |
| 英文摘要 | Two dinuclear platinum(IV) prodrugs were prepared from cisplatin and oxaliplatin, and tethered to amphiphilic biodegradable block copolymers. The polymeric dinuclear platinum(IV) prodrugs were allowed to self-assemble into nanomicelles, which showed reduced systemic toxicity, relatively long blood circulation, and enhanced antitumor efficacy. In this way, the bottleneck of present multinuclear platinum drugs, especially their severe systemic toxicity, might be overcome. (C) 2012 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000310401000044 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49491]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Jilin Univ, China Japan Union Hosp, Dept Colorectal & Anal Surg, Changchun 130033, Peoples R China 4.NE Normal Univ, Natl Engn Lab Druggable Gene & Prot Screening, Changchun 130024, Peoples R China 5.NE Normal Univ, Minist Educ, Res Ctr Agr & Med Gene Engn, Changchun 130024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Haihua,Song, Haiqin,Zhang, Yu,et al. The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy[J]. BIOMATERIALS,2012,33(33):8657-8669. |
| APA | Xiao, Haihua.,Song, Haiqin.,Zhang, Yu.,Qi, Ruogu.,Wang, Rui.,...&Jing, Xiabin.(2012).The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy.BIOMATERIALS,33(33),8657-8669. |
| MLA | Xiao, Haihua,et al."The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy".BIOMATERIALS 33.33(2012):8657-8669. |
入库方式： OAI收割
来源：化学研究所
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