Structural Effect and Mechanism of C70-Carboxyfullerenes as Efficient Sensitizers against Cancer Cells
文献类型：期刊论文
| 作者 | Liu, Qiaoling1; Guan, Mirong2; Xu, Li1; Shu, Chunying1; Jin, Chan3; Zheng, Junpeng2; Fang, Xiaohong1; Yang, Yongji3; Wang, Chunru1 |
| 刊名 | SMALL
 |
| 出版日期 | 2012-07-09 |
| 卷号 | 8期号:13页码:2070-2077 |
| 关键词 | Cancer Therapy Fullerenes Membrane Blebbing Photodynamic Therapy Photosensitizers |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201200158 |
| 英文摘要 | Carboxyfullerenes with different adduct numbers and cage sizes are tested as photosensitizers for photodynamic therapy (PDT). The photodynamic efficiency of these carboxyfullerenes depends mainly on the cage size, C60 versus C70, and to a lesser extent on the adduct numbers. In particular, malonic acid modified C70 fullerenes are more efficient than their C60 counterparts as photosensitizers, and the mechanism of cell death induced by C70-carboxyfullerene under light irradiation is investigated in detail. The results indicate that cell death occurs via necrosis accompanied by membrane blebbing, which is a unique phenomenon for photosensitizer-induced cell death. Since C70-carboxyfullerene displays an efficient PDT property and negligible dark cytotoxicity, it is promising for use in PDT applications, especially in vascular capillary diseases usually occurring under the surface. |
| 语种 | 英语 |
| WOS记录号 | WOS:000306011500015 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49529]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Shu, Chunying |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol,Inst Chem, Beijing 100049, Peoples R China 3.Second Mil Med Univ, Inst Biophys, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Qiaoling,Guan, Mirong,Xu, Li,et al. Structural Effect and Mechanism of C70-Carboxyfullerenes as Efficient Sensitizers against Cancer Cells[J]. SMALL,2012,8(13):2070-2077. |
| APA | Liu, Qiaoling.,Guan, Mirong.,Xu, Li.,Shu, Chunying.,Jin, Chan.,...&Wang, Chunru.(2012).Structural Effect and Mechanism of C70-Carboxyfullerenes as Efficient Sensitizers against Cancer Cells.SMALL,8(13),2070-2077. |
| MLA | Liu, Qiaoling,et al."Structural Effect and Mechanism of C70-Carboxyfullerenes as Efficient Sensitizers against Cancer Cells".SMALL 8.13(2012):2070-2077. |
入库方式： OAI收割
来源：化学研究所
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