Anti-tumor Activity of Biodegradable Polymer-paclitaxel Conjugated Micelle Against Mice U14 Cervical Cancers
文献类型：期刊论文
| 作者 | Chen Feng1; Dong Dan1; Fu Yan1; Zheng Yong-hui2; Liu Shi2; Chang Ming-xin3; Jing Xia-bin2 |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2012-07-25 |
| 卷号 | 28期号:4页码:656-661 |
| 关键词 | Cervical Cancer Polymer-drug Conjugate Paclitaxel Folic Acid Targeted Drug Delivery |
| ISSN号 | 1005-9040 |
| 英文摘要 | Two kinds of paclitaxel(PTX) conjugate micelles, of which one contained 25%(mass fraction) PTX [M(PTX)] and the other contained 22.5%(mass fraction) of PTX and 1.4%(mass fraction) of folate(FA)[FA-M(PTX)], were prepared for cell apoptosis and anti-tumor activity evaluation on U14 cervical cancer mouse models in comparison with 0.9%(mass fraction) saline(control) and equivalent Taxol. Seven days after tail intravenous injection of the drugs, the mice were sacrificed to measure the tumor masses. The average tumor masses were 4.26, 2.89, 2.63, and 2.17 g for the control, Taxol, M(PTX) and FA-M(PTX) groups, respectively. The inhibition rates of tumor growth calculated for the three drug groups were 32%, 38% and 49%, respectively. Flow cytometry(FC) analysis and terminal deoxynucleotidyl transferase(TdT)-mediated deoxyuridine triphosphate(dUTP) nick end labeling(TUNEL) assay were conducted on the cancer tissues. The cell apoptosis rates based on the FC data and the TUNEL data were 20%, 31%, 37%, 42%, and 10%, 22%, 26%, 34%, respectively, both showing statistically significant differences(P<0.05) between three drug groups and the control group, and between the FA-M(PTX) group and the other two drug groups. In conclusion, the composite FA-M(PTX) micelles can be used for U14 cervical cancer treatment. |
| 语种 | 英语 |
| WOS记录号 | WOS:000308279600022 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49555]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Fu Yan |
| 作者单位 | 1.Jilin Univ, Hosp 1, Changchun 130021, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.Changchun Univ Chinese Med, Affiliated Hosp, Changchun 130021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen Feng,Dong Dan,Fu Yan,et al. Anti-tumor Activity of Biodegradable Polymer-paclitaxel Conjugated Micelle Against Mice U14 Cervical Cancers[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2012,28(4):656-661. |
| APA | Chen Feng.,Dong Dan.,Fu Yan.,Zheng Yong-hui.,Liu Shi.,...&Jing Xia-bin.(2012).Anti-tumor Activity of Biodegradable Polymer-paclitaxel Conjugated Micelle Against Mice U14 Cervical Cancers.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,28(4),656-661. |
| MLA | Chen Feng,et al."Anti-tumor Activity of Biodegradable Polymer-paclitaxel Conjugated Micelle Against Mice U14 Cervical Cancers".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 28.4(2012):656-661. |
入库方式： OAI收割
来源：化学研究所
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