Fabrication of magnetic drug-loaded polymeric composite nanofibres and their drug release characteristics
文献类型：期刊论文
| 作者 | Wang, Linge1; Wang, Meng2; Topham, Paul D.3; Huang, Yong4,5 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2012 |
| 卷号 | 2期号:6页码:2433-2438 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c2ra00484d |
| 英文摘要 | Magnetic polymer nanofibres intended for drug delivery have been designed and fabricated by electrospinning. Magnetite (Fe3O4) nanoparticles were successfully incorporated into electrospun nanofibre composites of two cellulose derivatives, dehydroxypropyl methyl cellulose phthalate (HPMCP) and cellulose acetate (CA), while indomethacin (IDN) and aspirin have been used as model drugs. The morphology of the neat and magnetic drug-loaded electrospun fibres and the release characteristics of the drugs in artificial intestinal juice were investigated. It was found that both types of electrospun composite nanofibres containing magnetite nanoparticles showed superparamagnetism at room temperature, and their saturation magnetisation and morphology depend on the Fe3O4 nanoparticle content. Furthermore, the presence of the magnetite nanoparticles did not affect the drug release profiles of the nanofibrous devices. The feasibility of controlled drug release to a target area of treatment under the guidance of an external magnetic field has also been demonstrated, showing the viability of the concept of magnetic drug-loaded polymeric composite nanofibres for magneto-chemotherapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000300828400045 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49563]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Linge |
| 作者单位 | 1.Univ Sheffield, Dept Biomed Sci, Western Bank, Sheffield S10 2TN, S Yorkshire, England 2.Shenzhen Zhijun Pharmaceut Co Ltd, Shenzhen 518110, Peoples R China 3.Aston Univ, Birmingham B4 7ET, W Midlands, England 4.Chinese Acad Sci, Tech Inst Phys & Chem, Nat Res Ctr Engn Plast, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Linge,Wang, Meng,Topham, Paul D.,et al. Fabrication of magnetic drug-loaded polymeric composite nanofibres and their drug release characteristics[J]. RSC ADVANCES,2012,2(6):2433-2438. |
| APA | Wang, Linge,Wang, Meng,Topham, Paul D.,&Huang, Yong.(2012).Fabrication of magnetic drug-loaded polymeric composite nanofibres and their drug release characteristics.RSC ADVANCES,2(6),2433-2438. |
| MLA | Wang, Linge,et al."Fabrication of magnetic drug-loaded polymeric composite nanofibres and their drug release characteristics".RSC ADVANCES 2.6(2012):2433-2438. |
入库方式： OAI收割
来源：化学研究所
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