Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy
文献类型：期刊论文
| 作者 | Xiao, Haihua1,2; Li, Wenliang1,2; Qi, Ruogu1,2; Yan, Lesan1,2; Wang, Rui1,2; Liu, Shi1; Zheng, Yonghui1; Xie, Zhigang1; Huang, Yubin1; Jing, Xiabin1 |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2012-11-10 |
| 卷号 | 163期号:3页码:304-314 |
| 关键词 | Combination Chemotherapy Daunorubicin Drug Delivery Oxaliplatin Polymer Conjugates |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2012.06.004 |
| 英文摘要 | An oxaliplatin pro-drug (Oxa(IV)-COOH) with an axial carboxyl group was synthesized and conjugated to biodegradable polymers with pendant hydroxyl groups to prepare polymer-Oxa(IV) conjugates. A hydrophobic anthracycline-based drug, daunorubicin (DRB) was conjugated to similar biodegradable polymers with carboxyl groups to synthesize polymer-DRB conjugates. The two drug conjugates have the similar polymer backbone and are amphiphilic; thus, they can co-assemble into composite micelles. In the composite micelles, the polymer-Oxa(IV) conjugates can release clinically widely used water soluble anticancer drug oxaliplatin (Oxa(II)) upon reduction, while polymer-DRB conjugate is thought to release DRB via acid hydrolysis in the cancer cells. In this way, combination of the hydrophilic platinum drug Oxa(II) and hydrophobic drug DRB can be realized by delivering them in one platform. Moreover, the composite micelles showed reduced systematic toxicity and greater synergistic effect than combination of small molecules of the two anticancer drugs both in vitro and in vivo; thus, this polymer based combination therapy can be useful in future clinic application. (c) 2012 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000312266500005 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49597]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Haihua,Li, Wenliang,Qi, Ruogu,et al. Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy[J]. JOURNAL OF CONTROLLED RELEASE,2012,163(3):304-314. |
| APA | Xiao, Haihua.,Li, Wenliang.,Qi, Ruogu.,Yan, Lesan.,Wang, Rui.,...&Jing, Xiabin.(2012).Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy.JOURNAL OF CONTROLLED RELEASE,163(3),304-314. |
| MLA | Xiao, Haihua,et al."Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy".JOURNAL OF CONTROLLED RELEASE 163.3(2012):304-314. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。