Structural study and preliminary biological evaluation on the collagen hydrogel crosslinked by gamma-irradiation
文献类型：期刊论文
| 作者 | Zhang, Xiangmei1,2; Xu, Ling1,2,3; Huang, Xin1,2,4; Wei, Shicheng2,5; Zhai, Maolin6 |
| 刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
 |
| 出版日期 | 2012-11-01 |
| 卷号 | 100A期号:11页码:2960-2969 |
| 关键词 | Collagen Hydrogel Radiation Crosslinking Radiation Effect Biodegradation |
| ISSN号 | 1549-3296 |
| DOI | 10.1002/jbm.a.34243 |
| 英文摘要 | Under gamma-irradiation, concentrated collagen solutions yielded collagen hydrogels and liquid products. The molecular structure of collagen hydrogels and the source of the liquid products were studied. Furthermore, preliminary biological properties of the hydrogels were investigated. The results revealed that crosslinking occurred to form collagen hydrogel and the crosslinking density increased with the increasing of the absorbed dose, and the collagen hydrogels showed enhanced mechanical properties. Meanwhile, collagen underwent radiation degradation and water was squeezed out from hydrogel by contraction of hydrogel, yielding liquid products. Collagen hydrogels induced by gamma-irradiation maintained the backbone structure of collagen, and tyrosine partially involved in crosslinking. The irradiated collagen hydrogels have higher denatured temperature, can promote fibroblasts proliferation, and their degradation rate in vivo depended on the absorbed dose. The comprehensive results suggested that the collagen hydrogels prepared by radiation crosslinking preserved the triple helical conformation, possessed improved thermal stability and mechanical properties, excellent biocompatibility, which is expected to favor its application as biomaterials. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:29602969, 2012. |
| 语种 | 英语 |
| WOS记录号 | WOS:000309063400012 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49623]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Xu, Ling |
| 作者单位 | 1.Peking Univ, Coll Engn, Beijing Key Lab Solid Waste Utilizat & Management, Beijing 100871, Peoples R China 2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China 3.PKU HKUST ShenZhen HongKong Inst, Shenzhen Key Lab Polymer Sci, Shenzhen 518057, Peoples R China 4.Beijing Jishuitan Hosp, Dept Burns, Beijing 100035, Peoples R China 5.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China 6.Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiangmei,Xu, Ling,Huang, Xin,et al. Structural study and preliminary biological evaluation on the collagen hydrogel crosslinked by gamma-irradiation[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2012,100A(11):2960-2969. |
| APA | Zhang, Xiangmei,Xu, Ling,Huang, Xin,Wei, Shicheng,&Zhai, Maolin.(2012).Structural study and preliminary biological evaluation on the collagen hydrogel crosslinked by gamma-irradiation.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,100A(11),2960-2969. |
| MLA | Zhang, Xiangmei,et al."Structural study and preliminary biological evaluation on the collagen hydrogel crosslinked by gamma-irradiation".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 100A.11(2012):2960-2969. |
入库方式： OAI收割
来源：化学研究所
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