INHIBITION OF SKOV3 OVARIAN CANCER BY NANOMICELLES CONSTRUCTED FROM POLY(ETHYLENE GLYCOL)-b-POLY(LACTIDE-co-CARBONATE/PACLITAXEL) CONJUGATES
文献类型：期刊论文
| 作者 | Dong, Dan1; Chen, Feng1; Fu, Yan1; Wang, Rui2,3; Zheng, Yong-hui2; Jing, Xia-bin2 |
| 刊名 | ACTA POLYMERICA SINICA
 |
| 出版日期 | 2012-08-20 |
| 期号 | 8页码:915-922 |
| 关键词 | Ovarian Cancer Targeting Poly(Ethylene Glycol)-b-Poly(Lactide-co-carbonate) Folic Acid Paclitaxel |
| ISSN号 | 1000-3304 |
| DOI | 10.3724/SP.J.1105.2012.12083 |
| 英文摘要 | Two amphiphilic biodegradable block copolymers, poly(ethylene glycol)-b-poly(lactide-co-carbonate), were prepared and then conjugated with paclitaxel (PTX) and folic acid (FA), respectively, to form polymer-PTX conjugate and polymer-FA conjugate. These two conjugates were co-assembled into composite nanomicelles with an average diameter of ca. 50 nm, a PTX content of 27 wt% and a FA content of 1.4 wt%. Human ovarian cancer SKOV3 cells were cultured. MTT assay and flow cytometry analysis showed that Taxol,M(PTX) and FA-M(PTX) could inhibit the growth of SKOV3 cells at a PTX concentration of 10 mu g/mL,M(PTX) and FA-M (PTX) were more efficient than Taxol. Xenograft subcutaneous SKOV3 cancer models were constructed in balb/c mice. Inhibition of the tumor growth by Taxol, M (PTX) and FA:NI(PTX) was examined. At a dosage of 20 mg/kg, the tumor volume measurement, the tumor weight measurement on the 9th day and the survival curve all showed that Taxol,M(PTX) and FA-M(PTX) could inhibit the growth of the SKOV3 cancers, in the order of Taxol |
| 语种 | 英语 |
| WOS记录号 | WOS:000309198100019 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49673]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Dong, Dan |
| 作者单位 | 1.Jilin Univ, Hosp 1, Changchun 130021, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Dan,Chen, Feng,Fu, Yan,et al. INHIBITION OF SKOV3 OVARIAN CANCER BY NANOMICELLES CONSTRUCTED FROM POLY(ETHYLENE GLYCOL)-b-POLY(LACTIDE-co-CARBONATE/PACLITAXEL) CONJUGATES[J]. ACTA POLYMERICA SINICA,2012(8):915-922. |
| APA | Dong, Dan,Chen, Feng,Fu, Yan,Wang, Rui,Zheng, Yong-hui,&Jing, Xia-bin.(2012).INHIBITION OF SKOV3 OVARIAN CANCER BY NANOMICELLES CONSTRUCTED FROM POLY(ETHYLENE GLYCOL)-b-POLY(LACTIDE-co-CARBONATE/PACLITAXEL) CONJUGATES.ACTA POLYMERICA SINICA(8),915-922. |
| MLA | Dong, Dan,et al."INHIBITION OF SKOV3 OVARIAN CANCER BY NANOMICELLES CONSTRUCTED FROM POLY(ETHYLENE GLYCOL)-b-POLY(LACTIDE-co-CARBONATE/PACLITAXEL) CONJUGATES".ACTA POLYMERICA SINICA .8(2012):915-922. |
入库方式： OAI收割
来源：化学研究所
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