Delivery of Active DACH-Pt Anticancer Species by Biodegradable Amphiphilic Polymers Using Thiol-Ene Radical Addition
文献类型：期刊论文
| 作者 | Xiao, Haihua1,2; Zhou, Dongfang1,2; Liu, Shi1; Qi, Ruogu1,2; Zheng, Yonghui1; Huang, Yubin1; Jing, Xiabin1 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2012-03-01 |
| 卷号 | 12期号:3页码:367-373 |
| 关键词 | Cancer Therapy Drug Delivery Systems Micelles Oxaliplatin Thiol-ene Addition |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201100320 |
| 英文摘要 | A biodegradable and amphiphilic copolymer, mPEG-b-P(LA-co-MAC/TMA) that contains pendant 1,2-bidentate carboxyl groups is synthesized by thiol-ene radical addition and is further used to chelate with the active anticancer species (DACH-Pt) of oxaliplatin to form an mPEG-b-P(LA-co-MAC/TMA-Pt-DACH) complex. The polymer platinum complex can self-assemble into micelles. In vitro studies show that the DACH-Pt micelles display enhanced or comparable cytotoxicity against SKOV-3 and MCF-7 cancer cells, while they show reduced toxicity to HeLa cells compared with oxaliplatin. |
| 语种 | 英语 |
| WOS记录号 | WOS:000301052700008 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49763]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Haihua,Zhou, Dongfang,Liu, Shi,et al. Delivery of Active DACH-Pt Anticancer Species by Biodegradable Amphiphilic Polymers Using Thiol-Ene Radical Addition[J]. MACROMOLECULAR BIOSCIENCE,2012,12(3):367-373. |
| APA | Xiao, Haihua.,Zhou, Dongfang.,Liu, Shi.,Qi, Ruogu.,Zheng, Yonghui.,...&Jing, Xiabin.(2012).Delivery of Active DACH-Pt Anticancer Species by Biodegradable Amphiphilic Polymers Using Thiol-Ene Radical Addition.MACROMOLECULAR BIOSCIENCE,12(3),367-373. |
| MLA | Xiao, Haihua,et al."Delivery of Active DACH-Pt Anticancer Species by Biodegradable Amphiphilic Polymers Using Thiol-Ene Radical Addition".MACROMOLECULAR BIOSCIENCE 12.3(2012):367-373. |
入库方式： OAI收割
来源：化学研究所
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