Adsorption and desorption of doxorubicin on oxidized carbon nanotubes
文献类型：期刊论文
| 作者 | Wang, Yunxia1; Yang, Sheng-Tao1,2; Wang, Yanli1; Liu, Yuanfang1,3; Wang, Haifang1 |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2012-09-01 |
| 卷号 | 97页码:62-69 |
| 关键词 | Carbon Nanotubes Adsorption Desorption Serum Proteins Drug Delivery |
| ISSN号 | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2012.04.013 |
| 英文摘要 | Carbon nanotubes (CNTs) show promise as nano-drug carriers. To develop the CNT-based drug delivery systems, drug loading and release are two major issues. In this study, we systematically evaluated the adsorption and desorption of doxorubicin (DOX)on oxidized multi-walled CNTs (O-MWCNTs). Our results indicated that O-MWCNTs possessed a huge adsorption capacity for DOX (9.45 x 10(3) mg/g). Although the adsorption process was quite slow, the adsorption capacity kept high enough for the therapy while shortening the incubation time to 2 h (1.03 x 10(3) mg/g). The desorption of DOX from O-MWCNTs scarcely occurred while incubated in buffer solution at both pH 7.4 and pH 5.5, however, the lower pH did benefit the desorption. The presence of serum proteins facilitated the desorption of DOX significantly, because these proteins bound strongly to O-MWCNTs resulting in the partial surface of O-MWNCTs being occupied. Moreover, the adsorption time also affected the release of DOX from O-MWCNTs. Shortening the incubation time benefited the release of DOX. The implications to the drug loading and therapeutics of the CNT-based drug delivery systems are discussed. (C) 2012 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000306045000011 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49911]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Haifang |
| 作者单位 | 1.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China 2.SW Univ Nationalities, Coll Chem & Environm Protect Engn, Chengdu 610041, Peoples R China 3.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yunxia,Yang, Sheng-Tao,Wang, Yanli,et al. Adsorption and desorption of doxorubicin on oxidized carbon nanotubes[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2012,97:62-69. |
| APA | Wang, Yunxia,Yang, Sheng-Tao,Wang, Yanli,Liu, Yuanfang,&Wang, Haifang.(2012).Adsorption and desorption of doxorubicin on oxidized carbon nanotubes.COLLOIDS AND SURFACES B-BIOINTERFACES,97,62-69. |
| MLA | Wang, Yunxia,et al."Adsorption and desorption of doxorubicin on oxidized carbon nanotubes".COLLOIDS AND SURFACES B-BIOINTERFACES 97(2012):62-69. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。