Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers
文献类型：期刊论文
| 作者 | Li, Zhuang1,2; Kang, Hongliang1; Che, Ning1,2; Liu, Zhijing1,2; Li, Pingping1,2; Li, Weiwei1; Zhang, Chao1,2; Cao, Chun1,2; Liu, Ruigang1; Huang, Yong3 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2014-10-13 |
| 卷号 | 111页码:18-24 |
| ISSN号 | 0144-8617 |
| 关键词 | Core-sheath Nanofibers Electrospinning Cellulose Acetate Liposomes Naproxen Sustained Drug Release |
| DOI | 10.1016/j.carbpol.2014.04.017 |
| 英文摘要 | Naproxen (NAP) loaded nanofibers of different structures have been successfully prepared by electrospinning. The structures of the nanofibers are NAP and cellulose acetate (CA) mixed nanofibers (NF-1), nanofibers with NAP/CA mixed core and CA sheath (NF-2), and NAP loaded liposomes and sodium hyaluronate (HA-Na) mixed core with CA sheath (NF-3). The structure and morphology of the nanofibers were characterized and the drug release behaviors were investigated. It was found that NAP can disperse in the HA-Na or CA matrix in molecular level without formation of NAP crystals and dimers. The drug release behaviors of NF-1 and NF-2 show a non-Fickian diffusion mechanism, while the NF-3 shows a specific drug release behavior with a burst release within 8 h followed by a sustained drug release for 12 days. The particular two-stage drug release behavior of NF-3 nanofibers offers the materials promising applications as wound dressing materials. (C) 2014 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000340302100003 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49945]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Ruigang |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Tech Inst Phys & Chem, Natl Res Ctr Engn Plast, Being 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhuang,Kang, Hongliang,Che, Ning,et al. Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers[J]. CARBOHYDRATE POLYMERS,2014,111:18-24. |
| APA | Li, Zhuang.,Kang, Hongliang.,Che, Ning.,Liu, Zhijing.,Li, Pingping.,...&Huang, Yong.(2014).Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers.CARBOHYDRATE POLYMERS,111,18-24. |
| MLA | Li, Zhuang,et al."Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers".CARBOHYDRATE POLYMERS 111(2014):18-24. |
入库方式： OAI收割
来源：化学研究所
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