Silver-catalysed direct amination of unactivated C-H bonds of functionalized molecules
文献类型：期刊论文
| 作者 | Yang, Mingyu1,2,3; Su, Bo1,2,3; Wang, Yang1,2,3; Chen, Kang1,2,3; Jiang, Xingyu1,2,3; Zhang, Yun-Fei1,2,3; Zhang, Xi-Sha1,2,3; Chen, Guihua1,2,3; Cheng, Ye1,2,3; Cao, Zhichao1,2,3 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2014-08-01 |
| 卷号 | 5 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms5707 |
| 英文摘要 | Carbon-nitrogen bond formation from inert C-H bonds is an ideal organic transformation and a highly desirable method for the synthesis of N-containing molecules due to its high efficiency and atom economy. In this report, we develop a general reaction to achieve an unprecedented selective intramolecular amination of unactivated C-H bond in the absence of complex directing groups. Functionalized heterocyclic products are built up from readily available linear amines through simple and reliable silver catalysis, representing a new silver-based C-H functionalization. This method displays preference for primary sp(3) C-H bonds and exhibits distinct chemo- and regioselectivity compared to existing methods of direct amination (Hofmann-Loffler-Freytag reaction and nitrene insertion). The study highlights the manipulation of unfunctionalized groups in organic molecules to furnish complex structural units in the natural and bioactive molecules. |
| 语种 | 英语 |
| WOS记录号 | WOS:000341078900005 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49987]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Shi, Zhang-Jie |
| 作者单位 | 1.Peking Univ, BNLMS, Beijing 100871, Peoples R China 2.Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Coll Chem, Beijing 100871, Peoples R China 3.Peking Univ, Green Chem Ctr, Beijing 100871, Peoples R China 4.Peking Univ, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China 5.Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China 6.Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Mingyu,Su, Bo,Wang, Yang,et al. Silver-catalysed direct amination of unactivated C-H bonds of functionalized molecules[J]. NATURE COMMUNICATIONS,2014,5. |
| APA | Yang, Mingyu.,Su, Bo.,Wang, Yang.,Chen, Kang.,Jiang, Xingyu.,...&Shi, Zhang-Jie.(2014).Silver-catalysed direct amination of unactivated C-H bonds of functionalized molecules.NATURE COMMUNICATIONS,5. |
| MLA | Yang, Mingyu,et al."Silver-catalysed direct amination of unactivated C-H bonds of functionalized molecules".NATURE COMMUNICATIONS 5(2014). |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。