Glucose-responsive Hydrogels Based on ABA Triblock Copolymers Containing Phenylboronic Acid
文献类型：期刊论文
| 作者 | Yang, Ting; Deng, Xin-xing; Du, Fu-sheng; Li, Zi-chen |
| 刊名 | ACTA POLYMERICA SINICA
 |
| 出版日期 | 2014-11-20 |
| 期号 | 11页码:1553-1560 |
| 关键词 | Phenylboronic Acid Poly(Ethylene Oxide) Block Copolymer Glucose-responsive Hydrogel |
| ISSN号 | 1000-3304 |
| 英文摘要 | A new type of poly (ethylene oxide) (PEO) chain transfer reagent was synthesized and used to mediate the reversible addition fragmentation chain transfer (RAFT) polymerization of 3-(acrylamino) phenylboronic acid (AAPBA) to get three types of PAAPBA-b-PEO-b-PAABPA triblock copolymers with different PAAPBA lengths. The gelation of these copolymers at physiological pH was examined. It was found that hydrogel formation was dependent on the PAABPA block chain length when the block was too long, no stable gel can be obtained due to the high hydrophobicity of the PAABPA segment. The effects of temperature, polymer concentration and glucose on the rheological properties of the gel were investigated in detail. The results indicated that the formed hydrogels possess solid-like behavior, at high polymer concentrations, gels with high strength and high phase transfer temperature could be obtained. In the presence of high concentration of glucose, interaction of glucose with the PAAPBA block can lead to the increase of the hydrophilicity of the PAAPBA block, thus leading to the break of the hydrogel network with time and finally the gel dissolved in about 1.5 h. Finally, the hydrogels could load FITC-BSA in the hydrophilic regions, and the release profile of FITC-BSA was accelerated in the presence of glucose. |
| 语种 | 英语 |
| WOS记录号 | WOS:000346552800017 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50025]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Zi-chen |
| 作者单位 | Peking Univ, Coll Chem & Mol Engn, Key Lab Polymer Chem & Phys, Beijing Natl Lab Mol Sci,Minist Educ, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Ting,Deng, Xin-xing,Du, Fu-sheng,et al. Glucose-responsive Hydrogels Based on ABA Triblock Copolymers Containing Phenylboronic Acid[J]. ACTA POLYMERICA SINICA,2014(11):1553-1560. |
| APA | Yang, Ting,Deng, Xin-xing,Du, Fu-sheng,&Li, Zi-chen.(2014).Glucose-responsive Hydrogels Based on ABA Triblock Copolymers Containing Phenylboronic Acid.ACTA POLYMERICA SINICA(11),1553-1560. |
| MLA | Yang, Ting,et al."Glucose-responsive Hydrogels Based on ABA Triblock Copolymers Containing Phenylboronic Acid".ACTA POLYMERICA SINICA .11(2014):1553-1560. |
入库方式： OAI收割
来源：化学研究所
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