Irreversible Low Critical Solution Temperature Behaviors of Thermal-responsive OEGylated Poly(L-cysteine) Containing Disulfide Bonds
文献类型：期刊论文
| 作者 | Ma, Yinan; Fu, Xiaohui; Shen, Yong; Fu, Wenxin; Li, Zhibo |
| 刊名 | MACROMOLECULES
 |
| 出版日期 | 2014-07-22 |
| 卷号 | 47期号:14页码:4684-4689 |
| ISSN号 | 0024-9297 |
| DOI | 10.1021/ma501104s |
| 英文摘要 | Three cysteine derivatives were synthesized in high yield by ligating monomethoxy oligo(ethylene glycol) (OEG) to L-cysteine thiol group using sulfenyl chlorides. These OEG groups containing di-, tri-, and tetra-EG units were linked with L-cysteine via disulfide bond. The three monomers were then converted into corresponding N-carboxyanhydrides (NCAs) using triphosgene in THF. Subsequent ring-opening polymerization (ROP) of disulfide bond containing NCAs gave three poly-EG(x)-L-cysteine derivatives. The obtained poly-EG(x)-L-cysteine with x = 3 and 4 displayed thermal-responsive behaviors in water, but the temperature-induced phase transition was found surprisingly irreversible. Such irreversible thermal-responsive behaviors were attributed to cross-linking arising from disulfide bonds exchanges. Using PEG-NH2 as macroinitiator, we also prepared two PEG-b-poly-EG(x)-L-cysteine diblocks, which could undergo irreversible thermal-induced sol gel transition, which was caused by the disulfide bonds exchanging reactions. These hydrogels displayed partially shear-thinning and rapid recovery properties allowing new capabilities to construct stimuli-responsive injectable hydrogels in biomedical applications. |
| 语种 | 英语 |
| WOS记录号 | WOS:000339462900017 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50043]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Fu, Wenxin |
| 作者单位 | Chinese Acad Sci, Inst Chem, BNLMS, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Yinan,Fu, Xiaohui,Shen, Yong,et al. Irreversible Low Critical Solution Temperature Behaviors of Thermal-responsive OEGylated Poly(L-cysteine) Containing Disulfide Bonds[J]. MACROMOLECULES,2014,47(14):4684-4689. |
| APA | Ma, Yinan,Fu, Xiaohui,Shen, Yong,Fu, Wenxin,&Li, Zhibo.(2014).Irreversible Low Critical Solution Temperature Behaviors of Thermal-responsive OEGylated Poly(L-cysteine) Containing Disulfide Bonds.MACROMOLECULES,47(14),4684-4689. |
| MLA | Ma, Yinan,et al."Irreversible Low Critical Solution Temperature Behaviors of Thermal-responsive OEGylated Poly(L-cysteine) Containing Disulfide Bonds".MACROMOLECULES 47.14(2014):4684-4689. |
入库方式： OAI收割
来源：化学研究所
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