Nuclease-Functionalized Poly(Styrene-b-isobutylene-b-styrene) Surface with Anti-Infection and Tissue Integration Bifunctions
文献类型：期刊论文
| 作者 | Yuan, Shuaishuai1,3; Zhao, Jie2; Luan, Shifang1; Yan, Shunjie1,3; Zheng, Wanling1; Yin, Jinghua1 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2014-10-22 |
| 卷号 | 6期号:20页码:18078-18086 |
| 关键词 | Poly(Styrene-b-isobutylene-b-styrene) (Sibs) Deoxyribonuclease (Dnase) Ribonuclease (Rnase) Antibacterial Cell Adhesion |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/am504955g |
| 英文摘要 | Hydrophobic thermoplastic elastomers, e.g., poly(styrene-b-isobutylene-b-styrene) (SIBS), have found various in vivo biomedical applications. It has long been recognized that biomaterials can be adversely affected by bacterial contamination and clinical infection. However, inhibiting bacterial colonization while simultaneously preserving or enhancing tissue-cell/material interactions is a great challenge. Herein, SIBS substrates were functionalized with nucleases under mild conditions, through polycarboxylate grafts as intermediate. It was demonstrated that the nuclease-modified SIBS could effectively prevent bacterial adhesion and biofilm formation. Cell adhesion assays confirmed that nuclease coatings generally had no negative effects on L929 cell adhesion, compared with the virgin SIBS reference. Therefore, the as-reported nuclease coating may present a promising approach to inhibit bacterial infection, while preserving tissue-cell integration on polymeric biomaterials. |
| 语种 | 英语 |
| WOS记录号 | WOS:000343684200089 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50057]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Luan, Shifang |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Georgia So Univ, Dept Chem, Statesboro, GA 30460 USA 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Shuaishuai,Zhao, Jie,Luan, Shifang,et al. Nuclease-Functionalized Poly(Styrene-b-isobutylene-b-styrene) Surface with Anti-Infection and Tissue Integration Bifunctions[J]. ACS APPLIED MATERIALS & INTERFACES,2014,6(20):18078-18086. |
| APA | Yuan, Shuaishuai,Zhao, Jie,Luan, Shifang,Yan, Shunjie,Zheng, Wanling,&Yin, Jinghua.(2014).Nuclease-Functionalized Poly(Styrene-b-isobutylene-b-styrene) Surface with Anti-Infection and Tissue Integration Bifunctions.ACS APPLIED MATERIALS & INTERFACES,6(20),18078-18086. |
| MLA | Yuan, Shuaishuai,et al."Nuclease-Functionalized Poly(Styrene-b-isobutylene-b-styrene) Surface with Anti-Infection and Tissue Integration Bifunctions".ACS APPLIED MATERIALS & INTERFACES 6.20(2014):18078-18086. |
入库方式： OAI收割
来源：化学研究所
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