Fluorescence Light-Up Probe for Parallel G-Quadruplexes
文献类型：期刊论文
| 作者 | Jin, Bing1,2; Zhang, Xin1,2; Zheng, Wei1,2; Liu, Xiangjun1; Qi, Cui1,2; Wang, Fuyi1; Shangguan, Dihua1 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2014-01-07 |
| 卷号 | 86期号:1页码:943-952 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/ac403676x |
| 英文摘要 | Putative G-quadruplex-forming sequences (PQS) are highly prevalent in human genome; however, the structures and functions of most PQSs in genome are poorly understood. Therefore, selective recognition of certain types of G-quadruplexes (G4s) is important for the study of G4s. A new light up fluorescent probe, BPBC composed of benzimidazole and carbazole moieties was designed and synthesized. BPBC possesses a crescent-shaped pi-conjugated planar core that is slightly larger than the dimension of the G-quartet plane in G4s. This structure endows BPBC with excellent selectivity to parallel G4s. BPBC exhibits almost no fluorescence in the aqueous buffer condition, its fluorescence increases approximately 330-1800-fold in the presence of parallel G4s but only about 30-fold in the presence of single/double-stranded (ss/ds) DNA and 30-110-fold in the presence of antiparallel G4s. Binding studies indicate that the highly selective fluorescent response of BPBC arises from end-stack binding model to G-quartet. |
| 语种 | 英语 |
| WOS记录号 | WOS:000329548700107 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50083]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Shangguan, Dihua |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Bing,Zhang, Xin,Zheng, Wei,et al. Fluorescence Light-Up Probe for Parallel G-Quadruplexes[J]. ANALYTICAL CHEMISTRY,2014,86(1):943-952. |
| APA | Jin, Bing.,Zhang, Xin.,Zheng, Wei.,Liu, Xiangjun.,Qi, Cui.,...&Shangguan, Dihua.(2014).Fluorescence Light-Up Probe for Parallel G-Quadruplexes.ANALYTICAL CHEMISTRY,86(1),943-952. |
| MLA | Jin, Bing,et al."Fluorescence Light-Up Probe for Parallel G-Quadruplexes".ANALYTICAL CHEMISTRY 86.1(2014):943-952. |
入库方式： OAI收割
来源：化学研究所
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