Fabricating antigen recognition and anti-bioadhesion polymeric surface via a photografting polymerization strategy
文献类型：期刊论文
| 作者 | Song, Lingjie1,2; Zhao, Jie1; Jin, Jing1; Ma, Jiao1; Liu, Jingchuan1; Luan, Shifang1; Yin, Jinghua1 |
| 刊名 | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
 |
| 出版日期 | 2014-03-01 |
| 卷号 | 36页码:57-64 |
| 关键词 | Photografting Polymerization Anti-bioadhesion Antibody Immobilization |
| ISSN号 | 0928-4931 |
| DOI | 10.1016/j.msec.2013.11.044 |
| 英文摘要 | A polymeric platform for immunodiagnostic bioassay was constructed based on biostable polymeric support and two functional monomers, low-fouling methacryloyloxyethyl phosphorylcholine (MPC) and acrylic acid (AAc), by a photografting polymerization approach. Covalent binding of antibody to pAAc chains was achieved by activating carboxyl with NHS/EDC partner. The resultant surface showed obvious suppression of nonspecific protein adsorption and platelet adhesion relative to the control sample, exhibiting good anti-bioadhesion performances. Based on the polymer-supported matrix, a highly sensitive antibody-antigen specific recognition was confirmed in both native plasma and diluted human plasma due to the enhanced antibody loading capacity and lowered bioadhesion as compared to the reference. (C) 2013 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000331509300009 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50093]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Luan, Shifang |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Lingjie,Zhao, Jie,Jin, Jing,et al. Fabricating antigen recognition and anti-bioadhesion polymeric surface via a photografting polymerization strategy[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2014,36:57-64. |
| APA | Song, Lingjie.,Zhao, Jie.,Jin, Jing.,Ma, Jiao.,Liu, Jingchuan.,...&Yin, Jinghua.(2014).Fabricating antigen recognition and anti-bioadhesion polymeric surface via a photografting polymerization strategy.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,36,57-64. |
| MLA | Song, Lingjie,et al."Fabricating antigen recognition and anti-bioadhesion polymeric surface via a photografting polymerization strategy".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 36(2014):57-64. |
入库方式： OAI收割
来源：化学研究所
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