Highly sensitive and specific detection of histamine via the formation of a self-assembled magic number cluster with thymine by mass spectrometry
文献类型：期刊论文
| 作者 | Sun, Jiamu; Qin, Zhen; Liu, Jia; Zhang, Chengsen; Luo, Hai |
| 刊名 | ANALYST
 |
| 出版日期 | 2014 |
| 卷号 | 139期号:12页码:3154-3159 |
| ISSN号 | 0003-2654 |
| DOI | 10.1039/c3an02354k |
| 英文摘要 | A novel method for the detection of histamine (HIM) via the formation of a self-assembled magic number cluster with thymine (T) by electrospray ionization tandem mass spectrometry (ESI-MS/MS) is described. The formation of the magic number cluster [T-17 + HIM + 2H](2+) shifts the MS signal of histamine to the interference-free higher mass range and the signal intensity is increased by four orders of magnitude. In addition, the formation of [T-17 + HIM + 2H](2+) is highly specific to histamine compared with its metabolite and other similar biogenic amines, which may be attributed to both of its amino and imidazole groups. The linear dynamic range of the method is in the range of 1 nM-20 mu M, and the limit of detection can be as low as 0.1 nM. The feasibility of this method is further demonstrated by the quantitative analysis of histamine in a red wine sample. Since little sample preparation or separation is required before the analysis, this method provides a rapid new way for the sensitive and specific detection of histamine by MS. |
| 语种 | 英语 |
| WOS记录号 | WOS:000336737900029 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50113]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Luo, Hai |
| 作者单位 | Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Jiamu,Qin, Zhen,Liu, Jia,et al. Highly sensitive and specific detection of histamine via the formation of a self-assembled magic number cluster with thymine by mass spectrometry[J]. ANALYST,2014,139(12):3154-3159. |
| APA | Sun, Jiamu,Qin, Zhen,Liu, Jia,Zhang, Chengsen,&Luo, Hai.(2014).Highly sensitive and specific detection of histamine via the formation of a self-assembled magic number cluster with thymine by mass spectrometry.ANALYST,139(12),3154-3159. |
| MLA | Sun, Jiamu,et al."Highly sensitive and specific detection of histamine via the formation of a self-assembled magic number cluster with thymine by mass spectrometry".ANALYST 139.12(2014):3154-3159. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。