Transition metal-mediated bioorthogonal protein chemistry in living cells
文献类型：期刊论文
| 作者 | Yang, Maiyun1; Li, Jie1; Chen, Peng R.1,2 |
| 刊名 | CHEMICAL SOCIETY REVIEWS
 |
| 出版日期 | 2014-09-21 |
| 卷号 | 43期号:18页码:6511-6526 |
| ISSN号 | 0306-0012 |
| DOI | 10.1039/c4cs00117f |
| 英文摘要 | Considerable attention has been focused on improving the biocompatibility of Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), a hallmark of bioorthogonal reaction, in living cells. Besides creating copper-free versions of click chemistry such as strain promoted azide-alkyne cycloaddition (SPAAC), a central effort has also been made to develop various Cu(I) ligands that can prevent the cytotoxicity of Cu(I) ions while accelerating the CuAAC reaction. Meanwhile, additional transition metals such as palladium have been explored as alternative sources to promote a bioorthogonal conjugation reaction on cell surface, as well as within an intracellular environment. Furthermore, transition metal mediated chemical conversions beyond conjugation have also been utilized to manipulate protein activity within living systems. We highlight these emerging examples that significantly enriched our protein chemistry toolkit, which will likely expand our view on the definition and applications of bioorthogonal chemistry. |
| 语种 | 英语 |
| WOS记录号 | WOS:000340780400003 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50115]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Peng R. |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Synthet Funct Biomol Ctr,Minist Educ, Beijing Natl Lab Mol Sci,Key Lab Bioorgan Chem &, Beijing 100871, Peoples R China 2.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Maiyun,Li, Jie,Chen, Peng R.. Transition metal-mediated bioorthogonal protein chemistry in living cells[J]. CHEMICAL SOCIETY REVIEWS,2014,43(18):6511-6526. |
| APA | Yang, Maiyun,Li, Jie,&Chen, Peng R..(2014).Transition metal-mediated bioorthogonal protein chemistry in living cells.CHEMICAL SOCIETY REVIEWS,43(18),6511-6526. |
| MLA | Yang, Maiyun,et al."Transition metal-mediated bioorthogonal protein chemistry in living cells".CHEMICAL SOCIETY REVIEWS 43.18(2014):6511-6526. |
入库方式： OAI收割
来源：化学研究所
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