Fabrication of uniform sized polylactone microcapsules by premix membrane emulsification for ultrasound imaging
文献类型：期刊论文
| 作者 | Liu, Baoxia1; Zhou, Xiao2; Yang, Fei1; Shen, Hong1; Wang, Shenguo1; Zhang, Bo2; Zhi, Guang2; Wu, Decheng1 |
| 刊名 | POLYMER CHEMISTRY
 |
| 出版日期 | 2014-03-07 |
| 卷号 | 5期号:5页码:1693-1701 |
| ISSN号 | 1759-9954 |
| DOI | 10.1039/c3py01144e |
| 英文摘要 | An ultrasound contrast agent (UCA) plays a key role in ultrasound imaging to precisely diagnose coronary heart disease. Microcapsules composed of inner gas and shell materials are most commonly employed as ultrasound contrast agents. The ultrasonic properties of the microcapsules are significantly dependent on their size and size distribution. Herein, we prepared several uniform sized biodegradable polylactone microcapsules by combining a premix membrane emulsification technique and W/O/W method. We investigated various size-dependent factors to optimize the size and size distribution of the microcapsules. After evaluation for ultrasound imaging, similar to 4 mu m PLLA (poly(L-lactide)) microcapsules generated more intense ultrasound signals than PLGA7030 or PLGA5050 (poly(lactic-co-glycolic acid), the molar ratio of lactic acid and glycolic acid being 70 : 30 or 50 : 50), PEG-b-PLGA7030 (poly(ethylene glycop-block-poly(lactic-co-glycolic acid)), PLC5050 (poly(L-lactide-co-caprolactone), the molar ratio of lactide and caprolactone being 50 : 50) and PEG-b-PLLA microcapsules. The signal duration of the PLLA and PEG-PLLA microcapsules could reach ca. 3 and 3.5 min continuously. The ultrasound signal intensity and duration of the signals of PLLA microcapsules were considerably stronger and longer than those of commercially available UCAs, showing that the PLLA microcapsules have a great potential as more efficient UCAs for biomedical imaging. |
| 语种 | 英语 |
| WOS记录号 | WOS:000331987700020 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50369]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Fei |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Baoxia,Zhou, Xiao,Yang, Fei,et al. Fabrication of uniform sized polylactone microcapsules by premix membrane emulsification for ultrasound imaging[J]. POLYMER CHEMISTRY,2014,5(5):1693-1701. |
| APA | Liu, Baoxia.,Zhou, Xiao.,Yang, Fei.,Shen, Hong.,Wang, Shenguo.,...&Wu, Decheng.(2014).Fabrication of uniform sized polylactone microcapsules by premix membrane emulsification for ultrasound imaging.POLYMER CHEMISTRY,5(5),1693-1701. |
| MLA | Liu, Baoxia,et al."Fabrication of uniform sized polylactone microcapsules by premix membrane emulsification for ultrasound imaging".POLYMER CHEMISTRY 5.5(2014):1693-1701. |
入库方式： OAI收割
来源：化学研究所
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