Molecular Interactions of Bacterial Chemoreceptor Assemblies
文献类型：期刊论文
| 作者 | Yu Da-Qi1,2; Tu Yu-Hai2,3; Lai Lu-Hua1,2 |
| 刊名 | ACTA PHYSICO-CHIMICA SINICA
 |
| 出版日期 | 2014-07-01 |
| 卷号 | 30期号:7页码:1347-1353 |
| 关键词 | Chemoreceptor Assembly Molecular Interaction Protein-protein Docking Molecular Dynamics Simulation |
| ISSN号 | 1000-6818 |
| DOI | 10.3866/PKU.WHXB201404301 |
| 英文摘要 | Bacterial chemoreceptors form homodimers that assemble into large clusters on cell membranes to respond to external signals. These clusters have been found to have two different types of patterns: one is composed of inverted pyramid like trimers-of-dimers observed in the X-ray crystal structures, and the other is formed by the zipper like overlap of tips of dimers, as revealed by low-resolution electron microscopy. The detailed molecular model of the zipper like assemblies has remained unknown until now. Using protein-protein docking method, we studied the interactions between serine chemoreceptor Tsr dimers in Escherichia coli. The basic complexes for the two types of clustering patterns were both found in the docking complexes. Molecular dynamics simulations confirmed that these complexes were stable to a certain extent. Protein-protein interface analysis indicated that electrostatic and hydrophobic interactions are the dominant driving forces for zipper like complex formation. Arg388, Phe373, and Ile377 are the key interfacial residues that stabilize the zipper like complexes. The molecular models for the zipper like complexes provide insight into the mechanisms of bacterial chemoreceptor assemblies on membranes and serve as a basis for further theoretical and simulation studies. |
| 语种 | 英语 |
| WOS记录号 | WOS:000338837800020 |
| 出版者 | PEKING UNIV PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50427]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Lai Lu-Hua |
| 作者单位 | 1.Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China 2.Peking Univ, Ctr Quantitat Biol, Beijing 100871, Peoples R China 3.IBM TJ Watson Res Ctr, Yorktown Hts, NY 10598 USA |
| 推荐引用方式 GB/T 7714 | Yu Da-Qi,Tu Yu-Hai,Lai Lu-Hua. Molecular Interactions of Bacterial Chemoreceptor Assemblies[J]. ACTA PHYSICO-CHIMICA SINICA,2014,30(7):1347-1353. |
| APA | Yu Da-Qi,Tu Yu-Hai,&Lai Lu-Hua.(2014).Molecular Interactions of Bacterial Chemoreceptor Assemblies.ACTA PHYSICO-CHIMICA SINICA,30(7),1347-1353. |
| MLA | Yu Da-Qi,et al."Molecular Interactions of Bacterial Chemoreceptor Assemblies".ACTA PHYSICO-CHIMICA SINICA 30.7(2014):1347-1353. |
入库方式： OAI收割
来源：化学研究所
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