Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and alpha-cyclodextrin
文献类型：期刊论文
| 作者 | Kuang, Huihui1,2; He, Hongyan1,2; Zhang, Zhiyun1,2; Qi, Yanxin1; Xie, Zhigang1; Jinga, Xiabin1; Huang, Yubin1 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2014 |
| 卷号 | 2期号:6页码:659-667 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c3tb21475c |
| 英文摘要 | Injectable and biodegradable supramolecular hydrogels were prepared by nucleobase (adenine/thymine)terminated poly(ethylene oxide)s (A-PEG-A/T-PEG-T) and alpha-cyclodextrin (alpha-CD). The supramolecular hydrogels were thoroughly characterized by WXRD, rheometer, and SEM. The gelation time depended on the molecular weight of PEG and the concentration of polymer precursors. The rheological studies showed enhanced elastic modulus (G') of hydrogels, because of the hydrogen-bonding between A and T acting as additional network junctions. In vitro evaluation showed that the supramolecular hydrogels have acceptable biocompatibility, and are suitable for sustained and controlled release of loaded antitumor drugs. Gel formation was also confirmed when the supramolecular hydrogels were subcutaneously injected into rats. In addition, in vivo experiments employing U14 cancer cell xenograft-bearing mice showed that the intratumoral injection of a DOX-loaded A-PEG-A/T-PEG-T/alpha-CD gel inhibited tumor growth more effectively than that of free DOX, DOX-loaded PEG/alpha-CD gel, saline or gel alone. Hence, such a simple and convenient anti-cancer drug delivery system of a A-PEG-A/T-PEG-T/alpha-CD supramolecular hydrogel would be a promising candidate for many biomedical applications, especially in the area of the chemotherapy of solid tumors. |
| 语种 | 英语 |
| WOS记录号 | WOS:000329936400009 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50531]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Huang, Yubin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kuang, Huihui,He, Hongyan,Zhang, Zhiyun,et al. Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and alpha-cyclodextrin[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(6):659-667. |
| APA | Kuang, Huihui.,He, Hongyan.,Zhang, Zhiyun.,Qi, Yanxin.,Xie, Zhigang.,...&Huang, Yubin.(2014).Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and alpha-cyclodextrin.JOURNAL OF MATERIALS CHEMISTRY B,2(6),659-667. |
| MLA | Kuang, Huihui,et al."Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and alpha-cyclodextrin".JOURNAL OF MATERIALS CHEMISTRY B 2.6(2014):659-667. |
入库方式： OAI收割
来源：化学研究所
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