Hydrophilic Block Azidation of PCL-b-PEO Block Copolymers from Epichlorohydrin
文献类型：期刊论文
| 作者 | Liu, Junjie1,3; Gan, Zhihua1,2 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2014-05-01 |
| 卷号 | 14期号:5页码:699-708 |
| 关键词 | Block Copolymers Crosslinking Drug Delivery Systems Polymer Functionalization Polymers Self-assembly |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201300488 |
| 英文摘要 | Amphiphilic diblock copolymers poly(epsilon-caprolactone)-b-poly(ethylene oxide) (PCL-b-PEO) with well-controlled pendant azido groups along the hydrophilic PEO block, that is, poly-(epsilon-caprolactone)-b-poly(ethylene oxide-co-glycidyl azide) (PCL-b-P(EO-co-GA)), are synthesized from poly(epsilon-caprolactone)-b-poly(ethylene oxide-co-epichlorohydrin) (PCL-b-P(EO-co-ECH)). The further conversion of those azido groups along the hydrophilic block of copolymers into amino or carboxyl groups via click chemistry is studied. The micelles self-assembled from PCL-b-P(EO-co-GA) with azido groups on the shell are crosslinked by the dialkynyl-PEO. The micelles with crosslinked shell show better stability, higher drug loading capacities, subsequent faster drug release rate, and higher cytotoxicity to cancer cells. The introduction of azido groups into PCL-b-PEO amphiphilic diblock copolymers from epichlorohydrin in PEO hydrophilic block in this work provides a new method for biofunctionalization of micelles via mild click chemistry. |
| 语种 | 英语 |
| WOS记录号 | WOS:000336244100010 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50707]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Gan, Zhihua |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Engn Plast, Inst Chem, Beijing 100190, Peoples R China 2.Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing Lab Biomed Mat, Coll Life Sci & Technol, Beijing 100029, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Junjie,Gan, Zhihua. Hydrophilic Block Azidation of PCL-b-PEO Block Copolymers from Epichlorohydrin[J]. MACROMOLECULAR BIOSCIENCE,2014,14(5):699-708. |
| APA | Liu, Junjie,&Gan, Zhihua.(2014).Hydrophilic Block Azidation of PCL-b-PEO Block Copolymers from Epichlorohydrin.MACROMOLECULAR BIOSCIENCE,14(5),699-708. |
| MLA | Liu, Junjie,et al."Hydrophilic Block Azidation of PCL-b-PEO Block Copolymers from Epichlorohydrin".MACROMOLECULAR BIOSCIENCE 14.5(2014):699-708. |
入库方式： OAI收割
来源：化学研究所
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