A synergy effect between the hydrophilic PEG and rapid solvent evaporation induced formation of tunable porous microspheres from a triblock copolymer
文献类型：期刊论文
| 作者 | Fan, Jun-Bing1; Song, Yongyang1; Wang, Shutao1; Jiang, Lei1; Zhu, Ming-Qiang2; Guo, Xinglin1 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2014 |
| 卷号 | 4期号:2页码:629-633 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c3ra44197k |
| 英文摘要 | A uniform Evansblue-loaded biodegradable amphiphilic poly(lactide-co-glycolide-b-ethylene glycol-b-lactide-co-glycolide)(PLGE) porous microsphere prepared by a synergy effect between the hydrophilic PEG and rapid solvent evaporation is reported. Our approach is based on the double emulsion (W/O/W) in which solvent evaporates rapidly. We show the introduction of hydrophilic PEG and rapid solvent evaporation play an important role in the formation of biodegradable porous microspheres. The microsphere size, pore size and distribution as well as drug loading efficiency can be well controlled by varying the polymer compositions. Meanwhile, the drug release behaviors of PLGE porous microspheres are also discussed. |
| 语种 | 英语 |
| WOS记录号 | WOS:000327849700018 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50757]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Guo, Xinglin |
| 作者单位 | 1.Chinese Acad Sci, BNLMS, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China 2.Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Wuhan 430074, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Jun-Bing,Song, Yongyang,Wang, Shutao,et al. A synergy effect between the hydrophilic PEG and rapid solvent evaporation induced formation of tunable porous microspheres from a triblock copolymer[J]. RSC ADVANCES,2014,4(2):629-633. |
| APA | Fan, Jun-Bing,Song, Yongyang,Wang, Shutao,Jiang, Lei,Zhu, Ming-Qiang,&Guo, Xinglin.(2014).A synergy effect between the hydrophilic PEG and rapid solvent evaporation induced formation of tunable porous microspheres from a triblock copolymer.RSC ADVANCES,4(2),629-633. |
| MLA | Fan, Jun-Bing,et al."A synergy effect between the hydrophilic PEG and rapid solvent evaporation induced formation of tunable porous microspheres from a triblock copolymer".RSC ADVANCES 4.2(2014):629-633. |
入库方式： OAI收割
来源：化学研究所
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