Folate-targeted paclitaxel-conjugated polymeric micelles inhibits pulmonary metastatic hepatoma in experimental murine H22 metastasis models
文献类型：期刊论文
| 作者 | Zhang, Yan1; Zhang, Hui2; Wu, Wenbin2; Zhang, Fuhong3,4; Liu, Shi; Wang, Rui3; Sun, Yingchun1; Tong, Ti1; Jing, Xiabin3 |
| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
 |
| 出版日期 | 2014 |
| 卷号 | 9 |
| ISSN号 | 1178-2013 |
| 关键词 | Pulmonary Metastasis Folate Receptor Paclitaxel Polymer-drug Conjugate Targeted Drug Delivery |
| DOI | 10.2147/IJN.S57744 |
| 英文摘要 | Hepatocellular carcinoma shows low response to most conventional chemotherapies; additionally, extrahepatic metastasis from hepatoma is considered refractory to conventional systemic chemotherapy. Target therapy is a promising strategy for advanced hepatoma; however, targeted accumulation and controlled release of therapeutic agents into the metastatic site is still a great challenge. Folic acid (FA) and paclitaxel (PTX) containing composite micelles (FA-M[PTX]) were prepared by coassembling the FA polymer conjugate and PTX polymer conjugate. The main purpose of this study is to investigate the inhibitory efficacy of FA-M(PTX) on the pulmonary metastasis of intravenously injected murine hepatoma 22 (H22) on BALB/c mice models. The lung metastatic burden of H22 were measured and tissues were analyzed by immunohistochemistry and histology (hematoxylin and eosin stain), followed by survival analysis. The results indicated that FA-M(PTX) prevented pulmonary metastasis of H22, and the efficacy was stronger than pure PTX and simple PTX-conjugated micelles. In particular, the formation of lung metastasis colonies in mice was evidently inhibited, which was paralleled with the downregulated expression of matrix metalloproteinase-2 and matrix metalloproteinase-9. Furthermore, the mice bearing pulmonary metastatic hepatoma in the FA-M(PTX) group gained significantly prolonged survival time when compared with others given equivalent doses of PTX of 30 mg/kg. The enhanced efficacy of FA-M(PTX) is theoretically ascribed to the target effect of FA; moreover, the extensive pulmonary capillary networks may play a role. In conclusion, FA-M(PTX) displayed great potential as a promising antimetastatic agent, and the FA-conjugated micelles is a preferential targeted delivery system when compared to micelles without FA. |
| 语种 | 英语 |
| 出版者 | DOVE MEDICAL PRESS LTD |
| WOS记录号 | WOS:000334914500001 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50781]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Tong, Ti |
| 作者单位 | 1.Jilin Univ, Hosp 2, Dept Thorac Surg, Changchun 130041, Jilin, Peoples R China 2.Xuzhou Cent Hosp, Dept Thorac Surg, Xuzhou, Jiangsu, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 4.Lanzhou Univ, Hosp 1, Dept Otolaryngol, Lanzhou, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yan,Zhang, Hui,Wu, Wenbin,et al. Folate-targeted paclitaxel-conjugated polymeric micelles inhibits pulmonary metastatic hepatoma in experimental murine H22 metastasis models[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2014,9. |
| APA | Zhang, Yan.,Zhang, Hui.,Wu, Wenbin.,Zhang, Fuhong.,Liu, Shi.,...&Jing, Xiabin.(2014).Folate-targeted paclitaxel-conjugated polymeric micelles inhibits pulmonary metastatic hepatoma in experimental murine H22 metastasis models.INTERNATIONAL JOURNAL OF NANOMEDICINE,9. |
| MLA | Zhang, Yan,et al."Folate-targeted paclitaxel-conjugated polymeric micelles inhibits pulmonary metastatic hepatoma in experimental murine H22 metastasis models".INTERNATIONAL JOURNAL OF NANOMEDICINE 9(2014). |
入库方式： OAI收割
来源：化学研究所
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