Synthesis and properties of CO2-switchable Dex-g-PAHMA copolymers
文献类型：期刊论文
| 作者 | Che, Ning1,2; Yang, Saina1,2; Kang, Hongliang1; Liu, Ruigang1; Li, Zhuang1; Liu, Zhijing1,2; Li, Pingping1,2; Qu, Xiaozhong2; Huang, Yong1,3 |
| 刊名 | POLYMER CHEMISTRY
 |
| 出版日期 | 2014 |
| 卷号 | 5期号:24页码:7109-7120 |
| ISSN号 | 1759-9954 |
| DOI | 10.1039/c4py00987h |
| 英文摘要 | Dextran graft poly((N-amidino) hexyl methacrylamide) (Dex-g-PAHMA) copolymers were synthesized by free radical polymerization in aqueous solution and characterized. Dex-g-PAHMA copolymers can self-assemble into micelles with the PAHMA rich core and dextran rich shell in aqueous media. The CO2 sensitivity of the micelles was investigated by dynamic light scattering (DLS), conductivity and zeta potential. The results confirmed that the Dex-g-PAHMA copolymer micelles have reversible CO2 sensitivity. The micelles can be used as doxorubicin (DOX) carriers and DOX molecules are mainly located in the core of the micelles. The MTT assay indicated that the Dex-g-PAHMA graft copolymers are non-toxic to cells in the copolymer concentration range of 5-1000 mu g mL(-1), whereas the relative cell viability is greatly reduced with the increase of copolymer concentration for DOX-loaded micelles. The DOX-loaded micelles can be endocytosed by MCF-7 cells and the DOX can release from micelles and diffuse into the cell nucleus. The Dex-g-PAHMA copolymers have promising applications as drug carriers for cancer therapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000345066300025 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50791]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Ruigang |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Tech Inst Phys & Chem, Natl Res Ctr Engn Plast, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Che, Ning,Yang, Saina,Kang, Hongliang,et al. Synthesis and properties of CO2-switchable Dex-g-PAHMA copolymers[J]. POLYMER CHEMISTRY,2014,5(24):7109-7120. |
| APA | Che, Ning.,Yang, Saina.,Kang, Hongliang.,Liu, Ruigang.,Li, Zhuang.,...&Huang, Yong.(2014).Synthesis and properties of CO2-switchable Dex-g-PAHMA copolymers.POLYMER CHEMISTRY,5(24),7109-7120. |
| MLA | Che, Ning,et al."Synthesis and properties of CO2-switchable Dex-g-PAHMA copolymers".POLYMER CHEMISTRY 5.24(2014):7109-7120. |
入库方式： OAI收割
来源：化学研究所
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