Gold Nanorod-Embedded Electrospun Fibrous Membrane as a Photothermal Therapy Platform
文献类型：期刊论文
| 作者 | Cheng, Ming1; Wang, Heran2; Zhang, Zhen1; Li, Nan1; Fang, Xiaohong1; Xu, Shanshan2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2014-02-12 |
| 卷号 | 6期号:3页码:1569-1575 |
| 关键词 | Pegylated Gold Nanorods Electrospun Photothermal Therapy Biodegradable Membrane Cancer |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/am405839b |
| 英文摘要 | A strategy of using a gold nanorod (GNR)-loaded electrospun membrane as a photothermal therapy platform of cancer is reported. The strategy takes both the advantages of the excellent photothermal properties of GNRs to selectively kill the cancerous cells, and the widely used biodegradable electrospun membrane to serve as GNR-carrier and surgical recovery material. PEG modified GNRs. were embedded into the electrospun fibrous membrane which was composed of PLGA and PLA-b-PEG with an 85:15 ratio. After incubation with the cells in the cell culture medium, the PEG-GNRs were released from the membrane and taken up by cancer cells, allowing the generation of heat upon NIR irradiation to induce cancer cell death. We have demonstrated that the use of PEG-GNR-embedded membrane selectively killed the cancerous cells and effectively inhibited cancer cell proliferation though in vitro experiments. The PEG-GNRs-loaded membrane is a promising material for postsurgical recovery of cancer. |
| 语种 | 英语 |
| WOS记录号 | WOS:000331493200032 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50871]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Fang, Xiaohong |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Joint Lab Polymer Sci & Mat,Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Ming,Wang, Heran,Zhang, Zhen,et al. Gold Nanorod-Embedded Electrospun Fibrous Membrane as a Photothermal Therapy Platform[J]. ACS APPLIED MATERIALS & INTERFACES,2014,6(3):1569-1575. |
| APA | Cheng, Ming,Wang, Heran,Zhang, Zhen,Li, Nan,Fang, Xiaohong,&Xu, Shanshan.(2014).Gold Nanorod-Embedded Electrospun Fibrous Membrane as a Photothermal Therapy Platform.ACS APPLIED MATERIALS & INTERFACES,6(3),1569-1575. |
| MLA | Cheng, Ming,et al."Gold Nanorod-Embedded Electrospun Fibrous Membrane as a Photothermal Therapy Platform".ACS APPLIED MATERIALS & INTERFACES 6.3(2014):1569-1575. |
入库方式： OAI收割
来源：化学研究所
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