Nanoparticle delivery of photosensitive Pt(IV) drugs for circumventing cisplatin cellular pathway and on-demand drug release
文献类型：期刊论文
| 作者 | Du, Rong1; Xiao, Haihua2; Guo, Guannan1; Jiang, Bin1; Yan, Xing3; Li, Wenliang1,4; Yang, Xiaoguang3; Zhang, Yu3; Li, Yuxin3; Jing, Xiabin2 |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2014-11-01 |
| 卷号 | 123页码:734-741 |
| 关键词 | Drug Delivery System On-demand Drug Release Platinum Drug |
| ISSN号 | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2014.10.015 |
| 英文摘要 | A photosensitive platinum(IV) prodrug (UVA-Pt2) was attached to a biodegradable polymer (PE, methoxyl-poly(ethylene glycol)-block-poly(lactide-co-2-methyl-2-carboxyl-propylene carbonate-ethanol amine)) and then the conjugate was self-assembled to micelles (NP-UVA-Pt2). In vitro MU assay of NP-UVA-Pt2 demonstrated an improved cytotoxicity against SKOV-3 cells than that of cisplatin. Confocal laser scanning microscopy (GSM) indicated that NP-UVA-Pt2 were endocytosed rather than internalized by passive diffusion, and thus, this process has nothing to do with copper transporter protein (Ctr1) as reported for cisplatin, which is closely related to drug resistance of Pt based drugs. Intracellular platinum content measured by ICP-MS result suggested that NP-UVA-Pt2 expressed higher platinum intracellular uptake than cisplatin. NP-UVA-Pt2 demonstrated fast and robust response to photo irradiation while the nanoparticles were stable in PBS at PH7.4 in the dark. The great drug efficacy of NP-UVA-Pt2 under UVA irradiation and the ineffectiveness in the dark makes NP-UVA-Pt2 an ideal light responsive on-demand drug delivery system. Hence, NP-UVA-Pt2 will be a promising platinum based drug in the near future. (C) 2014 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000347580500090 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/50999]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Wenliang |
| 作者单位 | 1.NE Normal Univ, Natl Engn Lab Druggable Gene & Prot Screening, Changchun 130024, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.NE Normal Univ, Sch Iife Sci, Jilin Prov Key Lab Chem & Biol Nat Drugs Changbai, Changchun 130024, Peoples R China 4.Jilin Med Coll, Jilin 132013, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Rong,Xiao, Haihua,Guo, Guannan,et al. Nanoparticle delivery of photosensitive Pt(IV) drugs for circumventing cisplatin cellular pathway and on-demand drug release[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2014,123:734-741. |
| APA | Du, Rong.,Xiao, Haihua.,Guo, Guannan.,Jiang, Bin.,Yan, Xing.,...&Jing, Xiabin.(2014).Nanoparticle delivery of photosensitive Pt(IV) drugs for circumventing cisplatin cellular pathway and on-demand drug release.COLLOIDS AND SURFACES B-BIOINTERFACES,123,734-741. |
| MLA | Du, Rong,et al."Nanoparticle delivery of photosensitive Pt(IV) drugs for circumventing cisplatin cellular pathway and on-demand drug release".COLLOIDS AND SURFACES B-BIOINTERFACES 123(2014):734-741. |
入库方式： OAI收割
来源：化学研究所
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