System-level Study on Synergism and Antagonism of Active Ingredients in Traditional Chinese Medicine by Using Molecular Imprinting Technology
文献类型：期刊论文
| 作者 | Chen, Tengfei1; Gu, Jiangyong2; Zhang, Xinzhuang3; Ma, Yimin3; Cao, Liang3; Wang, Zhenzhong3; Chen, Lirong2; Xu, Xiaojie2; Xiao, Wei1,3 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2014-11-24 |
| 卷号 | 4 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep07159 |
| 英文摘要 | In this work, synergism and antagonism among active ingredients of traditional Chinese medicine (TCM) were studied at system-level by using molecular imprinting technology. Reduning Injection (RDNI), a TCM injection, was widely used to relieve fever caused by viral infection diseases in China. Molecularly imprinted polymers (MIPs) synthesized by sol-gel method were used to separate caffeic acid (CA) and analogues from RDNI without affecting other compounds. It can realize the preparative scale separation. The inhibitory effects of separated samples of RDNI and sample combinations in prostaglandin E-2 biosynthesis in lipopolysaccharide-induced RAW264.7 cells were studied. The combination index was calculated to evaluate the synergism and antagonism. We found that components which had different scaffolds can produce synergistic anti-inflammatory effect inside and outside the RDNI. Components which had similar scaffolds exhibited the antagonistic effect, and the antagonistic effects among components could be reduced to some extent in RDNI system. The results indicated MIPs with the characteristics of specific adsorption ability and large scale preparation can be an effective approach to study the interaction mechanism among active ingredients of complex system such as TCM at system-level. And this work would provide a new idea to study the interactions among active ingredients of TCM. |
| 语种 | 英语 |
| WOS记录号 | WOS:000346183900002 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51053]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Lirong |
| 作者单位 | 1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China 2.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, State Key Lab Rare Earth Mat Chem & Applicat, Beijing 100871, Peoples R China 3.Kanion Pharmaceut Corp, Natl Key Lab Pharmaceut New Technol Chinese Med, Lianyungang, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Tengfei,Gu, Jiangyong,Zhang, Xinzhuang,et al. System-level Study on Synergism and Antagonism of Active Ingredients in Traditional Chinese Medicine by Using Molecular Imprinting Technology[J]. SCIENTIFIC REPORTS,2014,4. |
| APA | Chen, Tengfei.,Gu, Jiangyong.,Zhang, Xinzhuang.,Ma, Yimin.,Cao, Liang.,...&Xiao, Wei.(2014).System-level Study on Synergism and Antagonism of Active Ingredients in Traditional Chinese Medicine by Using Molecular Imprinting Technology.SCIENTIFIC REPORTS,4. |
| MLA | Chen, Tengfei,et al."System-level Study on Synergism and Antagonism of Active Ingredients in Traditional Chinese Medicine by Using Molecular Imprinting Technology".SCIENTIFIC REPORTS 4(2014). |
入库方式： OAI收割
来源：化学研究所
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