Preparation of poly(cyclooctene)-g-poly(ethylene glycol) (PCOE-g-PEG) graft copolymers with tunable PEG side chains via ROMP and its protein adsorption and platelet adhesion properties
文献类型：期刊论文
| 作者 | Yang, Ying1; Shi, Dean1; Wang, Xueli1; Shi, Hengchong2; Jiang, Tao1; Yang, Yingkui1; Luan, Shifang2; Yin, Jinghua2; Li, Robert K. Y.3 |
| 刊名 | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
 |
| 出版日期 | 2014-12-01 |
| 卷号 | 45页码:539-545 |
| 关键词 | Romp Poly(Cyclooctene)-g-peg Tunable Protein Adsorption Platelet Adhesion |
| ISSN号 | 0928-4931 |
| DOI | 10.1016/j.msec.2014.10.010 |
| 英文摘要 | In our previous work [H. Shi, D. Shi et al., Polymer Chemistry 2(2011)679-684], polycyclooctene-g-PEG (PCOE-g-PEG) copolymers were synthesized via ring opening metathesis polymerization (ROMP) from PEG functionalized cyclic olefin macromonomers and cyclooctene. The grafting degree and the grafting site were easily controlled through the "grafting through" approach. The PCOE-g-PEG film surface was imparted excellent anti-protein adsorption properties. In that work, the molecular weight of PEG side chain was fixed at 750 g/mol and the neat PEG content in the copolymer was lower than 50 wt.%. In this work, both the effects of PEG side chain lengths.(350 to 1000 g/mol) at a fixed PEG content (50 wt.%) and the neat PEG content (30 wt.% to 70 wt.%) at a fixed PEG molecular weight (750 g/mol) on the anti-protein adsorption and anti-platelet adhesion properties are studied. It is shown that the copolymer with 60 wt.% PEG side chains of 750 g/mol, where both PEG and PCOE form continuous morphology, is optimal to reduce the adsorption of both the bovine serum albumin (BSA) and platelet When the PEG content reaches 70 wt.%, phase inversion happens. PEG is the continuous phase but PCOE becomes the dispersed phase. The surface roughness of the casting PCOE-g-PEG film increases. In this case, both BSA adsorption and platelet adhesion will slightly increase comparing to the sample with 60 wt.% PEG. (C) 2014 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000347582600069 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51163]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Shi, Dean |
| 作者单位 | 1.Hubei Univ, Fac Mat Sci & Engn, Key Lab Green Preparat & Applicat Funct Mat, Minist Educ, Wuhan 430062, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Ying,Shi, Dean,Wang, Xueli,et al. Preparation of poly(cyclooctene)-g-poly(ethylene glycol) (PCOE-g-PEG) graft copolymers with tunable PEG side chains via ROMP and its protein adsorption and platelet adhesion properties[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2014,45:539-545. |
| APA | Yang, Ying.,Shi, Dean.,Wang, Xueli.,Shi, Hengchong.,Jiang, Tao.,...&Li, Robert K. Y..(2014).Preparation of poly(cyclooctene)-g-poly(ethylene glycol) (PCOE-g-PEG) graft copolymers with tunable PEG side chains via ROMP and its protein adsorption and platelet adhesion properties.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,45,539-545. |
| MLA | Yang, Ying,et al."Preparation of poly(cyclooctene)-g-poly(ethylene glycol) (PCOE-g-PEG) graft copolymers with tunable PEG side chains via ROMP and its protein adsorption and platelet adhesion properties".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 45(2014):539-545. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。