Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry
文献类型：期刊论文
| 作者 | Hu, Yu1,2; Jin, Jing1; Han, Yuanyuan1; Yin, Jinghua1; Jiang, Wei1; Liang, Haojun3 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2014 |
| 卷号 | 4期号:15页码:7716-7724 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c3ra46934d |
| 英文摘要 | Protein adsorption behavior is a key factor that determines whether materials can be used as medical polymer materials. In this study, fibrinogen (Fib) adsorptions on three different poly(ethylene glycol) (PEG) surfaces that differed in chain length and chain density were investigated using a quartz crystal microbalance with dissipation (QCM-D) and a dual polarization interferometry (DPI) with respect to adsorbed masses, viscoelastic properties and chain conformations. On QCM-D chips, PEG chains were tight and in extended brush conformations. Meanwhile, on DPI chips, PEG(1000) and PEG(2000) may have the same pancake-like conformations, but PEG(5000) had a mushroom conformation. Moreover, several bare spaces were observed on the loose pancake-like PEG(1000)- and PEG(2000)-modified DPI surfaces. Fib could fully spread on the relatively dense PEG(1000)-modified DPI surface and partly spread and tightly orient on the relatively sparse PEG(2000)-modified DPI surface. Thus, grafting density was found to have greater significance in determining Fib adsorption resistance due to its influence on Fib spreading when the chain conformations of hydrophilic molecules were loose pancake-like structures. Furthermore, brush and mushroom structured PEG(5000) chains both had high deformation capacity, which excellently resisted protein adsorption by adjusting their conformation to decrease interaction with Fib. Therefore, the Fib adsorption resistance of PEG-modified surface depended on the grafting density of PEG layer and the deformation capacity of the PEG chain. |
| 语种 | 英语 |
| WOS记录号 | WOS:000330241000052 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51275]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jiang, Wei |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Univ Sci & Technol China, Dept Polymer Sci & Engn, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Yu,Jin, Jing,Han, Yuanyuan,et al. Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry[J]. RSC ADVANCES,2014,4(15):7716-7724. |
| APA | Hu, Yu,Jin, Jing,Han, Yuanyuan,Yin, Jinghua,Jiang, Wei,&Liang, Haojun.(2014).Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry.RSC ADVANCES,4(15),7716-7724. |
| MLA | Hu, Yu,et al."Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry".RSC ADVANCES 4.15(2014):7716-7724. |
入库方式： OAI收割
来源：化学研究所
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