Biological behavior of fibroblast on contractile collagen hydrogel crosslinked by gamma-irradiation
文献类型：期刊论文
| 作者 | Zhang, Xiangmei1,2; Zhang, Yaqing1,2; Chen, Wenqiang2; Xu, Ling1,2,3; Wei, Shicheng2,4; Zheng, Yufeng2; Zhai, Maolin5 |
| 刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
 |
| 出版日期 | 2014-08-01 |
| 卷号 | 102期号:8页码:2669-2679 |
| 关键词 | Collagen Hydrogel Radiation Crosslinking Contraction Fibroblasts |
| ISSN号 | 1549-3296 |
| DOI | 10.1002/jbm.a.34938 |
| 英文摘要 | Collagen hydrogels exhibited a contractile trend in simulated body fluid. In this study, the internal pore architecture and mechanical properties of collagen hydrogel prepared by radiation crosslinking was evaluated during contraction, and the effect of contractile collagen hydrogels on the biological behavior of fibroblasts were investigated in vitro, such as viability, proliferation, morphology, apoptosis, cycle, and stress fiber. The results showed that accompany with contraction of collagen hydrogel, the pore diameter of the hydrogels decreased and compressive modulus increased. However, fibroblasts can grow on contractile collagen hydrogels. Indeed, collagen hydrogel contracted from circumference to the interior, which retard the spreading of fibroblasts on the dynamic substrate and interrupted the initial attachment of the cell. However, contraction of collagen hydrogel had not only significant influence on the L929 cell proliferation, but also accelerated the apoptosis. Cell cycle analysis showed that contractile collagen hydrogel may promote cell cycle from G(0)/G(1) phase to S phase, and DNA synthesis and cell proliferation were enhanced, but which may be different in contraction process. Therefore, as a scaffold for tissue engineering, the strategy for inhibition of the contraction of collagen hydrogel should be taken into account. (C) 2013 Wiley Periodicals, Inc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000339964300020 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51357]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Xu, Ling |
| 作者单位 | 1.Peking Univ, Beijing Key Lab Solid Waste Utilizat & Management, Coll Engn, Beijing 100871, Peoples R China 2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China 3.Peking Univ, ShenZhen Inst, Shenzhen Key Lab Polymer Sci, Shenzhen 518057, Peoples R China 4.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China 5.Peking Univ, Beijing Natl Lab Mol Sci, Dept Appl Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiangmei,Zhang, Yaqing,Chen, Wenqiang,et al. Biological behavior of fibroblast on contractile collagen hydrogel crosslinked by gamma-irradiation[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2014,102(8):2669-2679. |
| APA | Zhang, Xiangmei.,Zhang, Yaqing.,Chen, Wenqiang.,Xu, Ling.,Wei, Shicheng.,...&Zhai, Maolin.(2014).Biological behavior of fibroblast on contractile collagen hydrogel crosslinked by gamma-irradiation.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,102(8),2669-2679. |
| MLA | Zhang, Xiangmei,et al."Biological behavior of fibroblast on contractile collagen hydrogel crosslinked by gamma-irradiation".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 102.8(2014):2669-2679. |
入库方式： OAI收割
来源：化学研究所
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