Advantages of proteins being disordered
文献类型：期刊论文
| 作者 | Liu, Zhirong1,2,3,4; Huang, Yongqi1,4,5 |
| 刊名 | PROTEIN SCIENCE
 |
| 出版日期 | 2014-05-01 |
| 卷号 | 23期号:5页码:539-550 |
| 关键词 | Intrinsically Disordered Proteins Protein Function Flexibility Protein-protein Interaction Molecular Recognition Protein Design Drug Design |
| ISSN号 | 0961-8368 |
| DOI | 10.1002/pro.2443 |
| 英文摘要 | The past decade has witnessed great advances in our understanding of protein structure-function relationships in terms of the ubiquitous existence of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs). The structural disorder of IDPs/IDRs enables them to play essential functions that are complementary to those of ordered proteins. In addition, IDPs/IDRs are persistent in evolution. Therefore, they are expected to possess some advantages over ordered proteins. In this review, we summarize and survey nine possible advantages of IDPs/IDRs: economizing genome/protein resources, overcoming steric restrictions in binding, achieving high specificity with low affinity, increasing binding rate, facilitating posttranslational modifications, enabling flexible linkers, preventing aggregation, providing resistance to non-native conditions, and allowing compatibility with more available sequences. Some potential advantages of IDPs/IDRs are not well understood and require both experimental and theoretical approaches to decipher. The connection with protein design is also briefly discussed. |
| 语种 | 英语 |
| WOS记录号 | WOS:000334592500004 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51495]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Zhirong |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Peking Univ, BNLMS, Beijing 100871, Peoples R China 3.Peking Univ, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China 4.Peking Univ, Ctr Quantitat Biol, Beijing 100871, Peoples R China 5.St Jude Childrens Res Hosp, Dept Biol Struct, Memphis, TN 38105 USA |
| 推荐引用方式 GB/T 7714 | Liu, Zhirong,Huang, Yongqi. Advantages of proteins being disordered[J]. PROTEIN SCIENCE,2014,23(5):539-550. |
| APA | Liu, Zhirong,&Huang, Yongqi.(2014).Advantages of proteins being disordered.PROTEIN SCIENCE,23(5),539-550. |
| MLA | Liu, Zhirong,et al."Advantages of proteins being disordered".PROTEIN SCIENCE 23.5(2014):539-550. |
入库方式： OAI收割
来源：化学研究所
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