Rapid Generation of Cell Gradients by Utilizing Solely Nanotopographic Interactions on a Bio-Inert Glass Surface
文献类型：期刊论文
| 作者 | Yang, Gao1,2; Cao, Yanhua1; Fan, Junbing1; Liu, Hongliang1; Zhang, Feilong1,2; Zhang, Pengchao1,2; Huang, Chao1; Jiang, Lei1; Wang, Shutao1 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2014-03-10 |
| 卷号 | 53期号:11页码:2915-2918 |
| 关键词 | Cell Gradients Chemical Modification Nanotopographic Gradient Topographic Interaction |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201309974 |
| 英文摘要 | The control of cell gradients is critical for understanding many biological systems and realizing the unique functionality of biomimetic implants. Herein, we report a nanotopographic gradient strategy that can rapidly generate cell gradients on a nanodendritic silica substrate without any chemical modification. We can achieve controllable cell gradients within only half an hour of cell incubation solely induced by the topographic effect of the gradient nanodendrites. We also demonstrate that cell gradients can be modulated by the combination of nanotopographic and chemical gradients. The results reveal that the enhanced topographic interactions between the nanodentritic structure and nanoscaled filopodia of the cells mainly contribute to the generation of cell gradients. |
| 语种 | 英语 |
| WOS记录号 | WOS:000336846300009 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51501]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Shutao |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, BNLMS, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Gao,Cao, Yanhua,Fan, Junbing,et al. Rapid Generation of Cell Gradients by Utilizing Solely Nanotopographic Interactions on a Bio-Inert Glass Surface[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014,53(11):2915-2918. |
| APA | Yang, Gao.,Cao, Yanhua.,Fan, Junbing.,Liu, Hongliang.,Zhang, Feilong.,...&Wang, Shutao.(2014).Rapid Generation of Cell Gradients by Utilizing Solely Nanotopographic Interactions on a Bio-Inert Glass Surface.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,53(11),2915-2918. |
| MLA | Yang, Gao,et al."Rapid Generation of Cell Gradients by Utilizing Solely Nanotopographic Interactions on a Bio-Inert Glass Surface".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53.11(2014):2915-2918. |
入库方式： OAI收割
来源：化学研究所
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