Bioreducible POSS-Cored Star-Shaped Polycation for Efficient Gene Delivery
文献类型：期刊论文
| 作者 | Yang, Yan-Yu1,2; Wang, Xing2; Hu, Yang1; Hu, Hao1; Wu, De-Cheng2; Xu, Fu-Jian1 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2014-01-22 |
| 卷号 | 6期号:2页码:1044-1052 |
| 关键词 | Poss Disulfide Bond Bioreducible Vector Gene Transfection |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/am404585d |
| 英文摘要 | The bioreducible star-shaped gene vector (POSS-(SS-PDMAEMA)(8)) with well-defined structure and relatively narrow molecular weight distribution was synthesized via atom transfer radical polymerization (ATRP) of (2-dimethylamino)ethyl methacrylate (DMAEMA) from a polyhedral oligomeric silsesquioxane (POSS) macroinitiator. POSS-(SS-PDMAEMA)(8) was composed of a biocompatible POSS core and eight disulfide-linked PDMAEMA arms, wherein the PDMAEMA chain length could be adjusted by controlling polymerization time. POSS-(SS-PDMAEMA)(8) can effectively bind pDNA into uniform nanocomplexes with appropriate particle size and zeta potential. The incorporation of disulfide bridges gave the POSS-(SS-PDMAEMA)(8) material facile bioreducibility. In comparison with POSS-(PDMAEMA)(8) without disulfide linkage, POSS-(SS-PDMAEMA)(8) exhibited much lower cytotoxicity and substantially higher transfection efficiency. The present work would provide useful information for the design of new POSS-based drug/gene carriers. |
| 语种 | 英语 |
| WOS记录号 | WOS:000330201900043 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51513]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wu, De-Cheng |
| 作者单位 | 1.Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing Lab Biomed Mat,State Key Lab Chem Resourc, Key Lab Carbon Fiber & Funct Polymers,Minist Educ, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Bening Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yan-Yu,Wang, Xing,Hu, Yang,et al. Bioreducible POSS-Cored Star-Shaped Polycation for Efficient Gene Delivery[J]. ACS APPLIED MATERIALS & INTERFACES,2014,6(2):1044-1052. |
| APA | Yang, Yan-Yu,Wang, Xing,Hu, Yang,Hu, Hao,Wu, De-Cheng,&Xu, Fu-Jian.(2014).Bioreducible POSS-Cored Star-Shaped Polycation for Efficient Gene Delivery.ACS APPLIED MATERIALS & INTERFACES,6(2),1044-1052. |
| MLA | Yang, Yan-Yu,et al."Bioreducible POSS-Cored Star-Shaped Polycation for Efficient Gene Delivery".ACS APPLIED MATERIALS & INTERFACES 6.2(2014):1044-1052. |
入库方式： OAI收割
来源：化学研究所
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