Systems pharmacology strategies for anticancer drug discovery based on natural products
文献类型：期刊论文
| 作者 | Luo, Fang; Gu, Jiangyong; Chen, Lirong; Xu, Xiaojie |
| 刊名 | MOLECULAR BIOSYSTEMS
 |
| 出版日期 | 2014 |
| 卷号 | 10期号:7页码:1912-1917 |
| ISSN号 | 1742-206X |
| DOI | 10.1039/c4mb00105b |
| 英文摘要 | Cancer is a complex disease, known medically as malignant neoplasm. Natural products (NPs) play a very important role in anticancer drug discovery and a large number of NPs have been proven to have potential anticancer effects. Compared with newly synthesized chemical compounds, NPs show a favorable profile in terms of their absorption and metabolism in the body with low toxicity. Searching for multi-target natural drugs can be regarded as a solution to improve therapeutic efficacy and safety. In this work, we collected 104 cancer-associated target proteins from the Protein Data Bank. Based on the Universal Natural Products Database, all of the NPs were docked to 104 cancer-associated target proteins. Then we explored the potential of NPs and several herbs in anticancer drug discovery by using a network-based multi-target computational approach. The NPs with the most potential for anticancer drug discovery and their indications were predicted based on a docking score-weighted prediction model. We also explored the interactions between NPs and cancer target proteins to find the pathological networks, potential drug candidates and new indications. |
| 语种 | 英语 |
| WOS记录号 | WOS:000337103600028 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51531]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Lirong |
| 作者单位 | Peking Univ, Coll Chem & Mol Engn, State Key Lab Rare Earth Mat Chem & Applicat, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Fang,Gu, Jiangyong,Chen, Lirong,et al. Systems pharmacology strategies for anticancer drug discovery based on natural products[J]. MOLECULAR BIOSYSTEMS,2014,10(7):1912-1917. |
| APA | Luo, Fang,Gu, Jiangyong,Chen, Lirong,&Xu, Xiaojie.(2014).Systems pharmacology strategies for anticancer drug discovery based on natural products.MOLECULAR BIOSYSTEMS,10(7),1912-1917. |
| MLA | Luo, Fang,et al."Systems pharmacology strategies for anticancer drug discovery based on natural products".MOLECULAR BIOSYSTEMS 10.7(2014):1912-1917. |
入库方式： OAI收割
来源：化学研究所
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