Mass Spectrometric Proteomics Reveals that Nuclear Protein Positive Cofactor PC4 Selectively Binds to Cross-Linked DNA by a trans-Platinum Anticancer Complex
文献类型：期刊论文
| 作者 | Du, Zhifeng1; Luo, Qun1; Yang, Liping2; Bing, Tao1; Li, Xianchan1; Guo, Wei1; Wu, Kui1; Zhao, Yao1; Xiong, Shaoxiang1; Shangguan, Dihua1 |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2014-02-26 |
| 卷号 | 136期号:8页码:2948-2951 |
| ISSN号 | 0002-7863 |
| DOI | 10.1021/ja410678y |
| 英文摘要 | An MS-based proteomic strategy combined with chemically functionalized gold nanoparticles as affinity probes was developed and validated by successful identification and quantification of HMGB1, which is well characterized to interact selectively with 1,2-cross-linked DNA by cisplatin, from whole cell lysates. The subsequent application of this method to identify proteins responding to 1,3-cross-linked DNA by a trans-platinum anticancer complex, trans-PtTz (Tz = thiazole), revealed that the human nuclear protein positive cofactor PC4 selectively binds to the damaged DNA, implying that PC4 may play a role in cellular response to DNA damage by trans-PtTz. |
| 语种 | 英语 |
| WOS记录号 | WOS:000332144300004 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51533]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Fuyi |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 2.Nantong Univ, Tumor Hosp, Canc Res Ctr, Nantong 226361, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Zhifeng,Luo, Qun,Yang, Liping,et al. Mass Spectrometric Proteomics Reveals that Nuclear Protein Positive Cofactor PC4 Selectively Binds to Cross-Linked DNA by a trans-Platinum Anticancer Complex[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2014,136(8):2948-2951. |
| APA | Du, Zhifeng.,Luo, Qun.,Yang, Liping.,Bing, Tao.,Li, Xianchan.,...&Wang, Fuyi.(2014).Mass Spectrometric Proteomics Reveals that Nuclear Protein Positive Cofactor PC4 Selectively Binds to Cross-Linked DNA by a trans-Platinum Anticancer Complex.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,136(8),2948-2951. |
| MLA | Du, Zhifeng,et al."Mass Spectrometric Proteomics Reveals that Nuclear Protein Positive Cofactor PC4 Selectively Binds to Cross-Linked DNA by a trans-Platinum Anticancer Complex".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136.8(2014):2948-2951. |
入库方式： OAI收割
来源：化学研究所
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