Reaction Rate Theory of Radiation Exposure and Scaling Hypothesis in Mutation Frequency
文献类型：期刊论文
| 作者 | Manabe, Yuichiro1; Nakamura, Issei2; Bando, Masako3,4 |
| 刊名 | JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN
 |
| 出版日期 | 2014-11-15 |
| 卷号 | 83期号:11 |
| ISSN号 | 0031-9015 |
| DOI | 10.7566/JPSJ.83.114003 |
| 英文摘要 | We have developed a kinetic reaction model for cells with irradiated DNA molecules due to ionizing radiation exposure. Our theory simultaneously accounts for the time-dependent reactions of DNA damage, DNA mutation and DNA repair, and the proliferation and apoptosis of cells in a tissue with a minimal set of model parameters. In contrast to existing theories of radiation exposition, we do not assume the relationships between the total dose and the induced mutation frequency. Our theory provides a universal scaling function that reasonably explains the mega-mouse experiments by Russell and Kelly [Proc. Natl. Acad. Sci. U.S.A. 79, 542 (1982)] with different dose rates. Furthermore, we have estimated the effective dose rate, which is biologically equivalent to the ionizing effects other than those caused by artificial irradiation. This value is 1.11 x 10(-3) Gy/h, which is significantly larger than the effect caused by natural background radiation. |
| 语种 | 英语 |
| WOS记录号 | WOS:000344653100015 |
| 出版者 | PHYSICAL SOC JAPAN |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51547]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Manabe, Yuichiro |
| 作者单位 | 1.Osaka Univ, Grad Sch Engn, Div Sustainable Energy & Environm Engn, Suita, Osaka 5650871, Japan 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.Kyoto Univ, Yukawa Inst Theoret Phys, Kyoto 6068502, Japan 4.Osaka Univ, Res Ctr Nucl Phys, Ibaraki, Osaka 5670047, Japan |
| 推荐引用方式 GB/T 7714 | Manabe, Yuichiro,Nakamura, Issei,Bando, Masako. Reaction Rate Theory of Radiation Exposure and Scaling Hypothesis in Mutation Frequency[J]. JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN,2014,83(11). |
| APA | Manabe, Yuichiro,Nakamura, Issei,&Bando, Masako.(2014).Reaction Rate Theory of Radiation Exposure and Scaling Hypothesis in Mutation Frequency.JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN,83(11). |
| MLA | Manabe, Yuichiro,et al."Reaction Rate Theory of Radiation Exposure and Scaling Hypothesis in Mutation Frequency".JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN 83.11(2014). |
入库方式： OAI收割
来源：化学研究所
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