Co-Delivery of Oxaliplatin and Demethylcantharidin via a Polymer-Drug Conjugate
文献类型：期刊论文
| 作者 | Wang, Enhui1; Xiong, Hejian2,3; Zhou, Dongfang2; Xie, Zhigang2; Huang, Yubin2; Jing, Xiabin2; Sun, Xinhua1 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2014-04-01 |
| 卷号 | 14期号:4页码:588-596 |
| 关键词 | Co-delivery Combination Chemotherapy Oxaliplatin Polymer-drug Conjugate Pp2a Inhibition |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201300402 |
| 英文摘要 | A Pt (IV) complex which combined the bioactivities of both oxaliplatin and demethylcantharidin (DMC) is synthesized and delivered by a polymer-drug conjugate for combination chemotherapy. Oxaliplatin is released from the polymer-drug conjugate within cancer cell by reduction to attack nuclear DNA, while a dose of DMC is also hydrolyzed subsequently to block DNA damage-induced defense mechanisms by serine/threonine phosphatase 2A (PP2A) inhibition. In vitro evaluation shows that the polymer-drug conjugate with dual modes of action upon cancer cells displays higher cytotoxicity against SKOV-3 cells than that of free drugs. This enhanced cytotoxicity is attributed to the synergistic effect between oxaliplatin and DMC, as well as the effective intracellular internalization of the micelles observed by confocal laser scanning microscopy (CLSM) imaging. |
| 语种 | 英语 |
| WOS记录号 | WOS:000334346400014 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51551]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhou, Dongfang |
| 作者单位 | 1.Jilin Univ, Fac Stomatol, Dept Orthodont, Changchun 130021, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Enhui,Xiong, Hejian,Zhou, Dongfang,et al. Co-Delivery of Oxaliplatin and Demethylcantharidin via a Polymer-Drug Conjugate[J]. MACROMOLECULAR BIOSCIENCE,2014,14(4):588-596. |
| APA | Wang, Enhui.,Xiong, Hejian.,Zhou, Dongfang.,Xie, Zhigang.,Huang, Yubin.,...&Sun, Xinhua.(2014).Co-Delivery of Oxaliplatin and Demethylcantharidin via a Polymer-Drug Conjugate.MACROMOLECULAR BIOSCIENCE,14(4),588-596. |
| MLA | Wang, Enhui,et al."Co-Delivery of Oxaliplatin and Demethylcantharidin via a Polymer-Drug Conjugate".MACROMOLECULAR BIOSCIENCE 14.4(2014):588-596. |
入库方式： OAI收割
来源：化学研究所
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