Role of ICAM-1 polymorphisms (G241R, K469E) in mediating its single-molecule binding ability: Atomic force microscopy measurements on living cells
文献类型：期刊论文
| 作者 | Bai, Rui1; Yi, Shaoqiong4; Zhang, Xuejie3; Liu, Huiliang2; Fang, Xiaohong3 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2014-06-13 |
| 卷号 | 448期号:4页码:372-378 |
| 关键词 | Intercellular Adhesion Molecule-1 Gene Polymorphisms Atomic Force Microscopy Single Molecule Force |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2014.04.113 |
| 英文摘要 | Atherosclerosis (As) is characterized by chronic inflammation and is a major cause of human mortality. ICAM-1-mediated adhesion of leukocytes in vessel walls plays an important role in the pathogenesis of atherosclerosis. Two single nucleotide polymorphisms (SNPs) of human intercellular adhesion molecule-1 (ICAM-1), G241R and K469E, are associated with a number of inflammatory diseases. SNP induced changes in ICAM-1 function rely not only on the expression level but also on the single-molecule binding ability which may be affected by single molecule conformation variations such as protein splicing and folding. Previous studies have shown associations between G241R/K469E polymorphisms and ICAM-1 gene expression. Nevertheless, few studies have been done that focus on the single-molecule forces of the above SNPs and their ligands. |
| 语种 | 英语 |
| WOS记录号 | WOS:000337260900005 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51669]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Huiliang |
| 作者单位 | 1.Chinese 301 Gen Hosp, Beijing 100853, Peoples R China 2.Chinese Peoples Armed Police Forces, Gen Hosp, Dept Cardiol, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 4.Beijing Inst Biotechnol, Beijing 100071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Rui,Yi, Shaoqiong,Zhang, Xuejie,et al. Role of ICAM-1 polymorphisms (G241R, K469E) in mediating its single-molecule binding ability: Atomic force microscopy measurements on living cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,448(4):372-378. |
| APA | Bai, Rui,Yi, Shaoqiong,Zhang, Xuejie,Liu, Huiliang,&Fang, Xiaohong.(2014).Role of ICAM-1 polymorphisms (G241R, K469E) in mediating its single-molecule binding ability: Atomic force microscopy measurements on living cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,448(4),372-378. |
| MLA | Bai, Rui,et al."Role of ICAM-1 polymorphisms (G241R, K469E) in mediating its single-molecule binding ability: Atomic force microscopy measurements on living cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 448.4(2014):372-378. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。