Diversity-oriented synthesis of Lycopodium alkaloids inspired by the hidden functional group pairing pattern
文献类型：期刊论文
| 作者 | Zhang, Jing1,2; Wu, Jinbao1,2; Hong, Benke1,2; Ai, Wenying1,2; Wang, Xiaoming1,2; Li, Houhua2; Lei, Xiaoguang2,3,4 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2014-08-01 |
| 卷号 | 5 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms5614 |
| 英文摘要 | Natural products continue to provide a rich source of inspiration for both chemists and biologists. The efficient synthesis of bioactive natural products or natural product-like molecules has offered tremendous opportunities for complex biological processes exploration and drug discovery. However, because natural products usually contain numerous stereogenic centres and polycyclic ring systems, significant synthetic challenges remain. Here we employ the build/couple/pair strategy that is frequently used in diversity-oriented synthesis to obtain skeletally diverse compounds with complexities comparable to natural products. Inspired by the functional group pairing patterns hidden in Lycopodium alkaloids, we efficiently and in parallel construct four natural products, (-)-Serratezomine A, (-)-Serratinine, (-)-8 alpha-Hydroxyfawcettimine and (-)-Lycoposerramine-U, as well as six different unnatural scaffolds, following the advanced build/couple/pair algorithm. This newly developed strategy is expected to be applied to the efficient synthesis of other complex natural products possessing functional group pairing patterns as well as skeletally diverse natural product-like molecules. |
| 语种 | 英语 |
| WOS记录号 | WOS:000341057000005 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51679]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Lei, Xiaoguang |
| 作者单位 | 1.Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China 2.NIBS, Beijing 102206, Peoples R China 3.Peking Univ, Coll Chem & Mol Engn, Synthet & Funct Biomol Ctr, Dept Biol Chem,Beijing Natl Lab Mol Sci,Key Lab B, Beijing 100871, Peoples R China 4.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jing,Wu, Jinbao,Hong, Benke,et al. Diversity-oriented synthesis of Lycopodium alkaloids inspired by the hidden functional group pairing pattern[J]. NATURE COMMUNICATIONS,2014,5. |
| APA | Zhang, Jing.,Wu, Jinbao.,Hong, Benke.,Ai, Wenying.,Wang, Xiaoming.,...&Lei, Xiaoguang.(2014).Diversity-oriented synthesis of Lycopodium alkaloids inspired by the hidden functional group pairing pattern.NATURE COMMUNICATIONS,5. |
| MLA | Zhang, Jing,et al."Diversity-oriented synthesis of Lycopodium alkaloids inspired by the hidden functional group pairing pattern".NATURE COMMUNICATIONS 5(2014). |
入库方式： OAI收割
来源：化学研究所
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