In vitro and in vivo photothermally enhanced chemotherapy by single-walled carbon nanohorns as a drug delivery system
文献类型：期刊论文
| 作者 | Chen, Daiqin1; Wang, Chao2; Jiang, Feng1; Liu, Zhuang2; Shu, Chunying1; Wan, Li-Jun1 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2014 |
| 卷号 | 2期号:29页码:4726-4732 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c4tb00249k |
| 英文摘要 | Single-walled carbon nanohorns (SWNHs) have exhibited many special advantages in biomedical applications. Herein, doxorubicin-loaded SWNHs (DOX-SWNHs) are prepared and further modified by amphiphilic deoxycholic acid modified-hydropropyl chitosan (DCA-HPCHS) to improve their biocompatibility. The obtained DOX-SWNH/DCA-HPCHS drug delivery system (DDS) possesses high stability in physiological media and excellent photothermal properties when exposed to laser irradiation in the near-infrared (NIR) region, which dramatically enhances the chemotherapy of DOX. Cell viability assays show that the growth of 4T1 cells are remarkably inhibitory under the conditions of incubation with DOX-SWNH/DCA-HPCHS and subsequent exposure to 808 nm laser irradiation to produce mild photothermal heating to 43 degrees C. Further investigation reveals that the photothermally enhanced chemotherapy derived from a promotion of DOX-SWNH/DCA-HPCHS uptake by the cancer cells rather than a light-triggered release of DOX. DOX-SWNH/DCA-HPCHS in combination with the use of laser irradiation exhibits a much better anticancer effect than the controls. Hence, the DOX-SWNH/DCA-HPCHS as a multifunctional DDS has been proposed and is hopeful for medicinal use in the future. |
| 语种 | 英语 |
| WOS记录号 | WOS:000339004600015 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51735]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wan, Li-Jun |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Inst Chem, Beijing 100190, Peoples R China 2.Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Daiqin,Wang, Chao,Jiang, Feng,et al. In vitro and in vivo photothermally enhanced chemotherapy by single-walled carbon nanohorns as a drug delivery system[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(29):4726-4732. |
| APA | Chen, Daiqin,Wang, Chao,Jiang, Feng,Liu, Zhuang,Shu, Chunying,&Wan, Li-Jun.(2014).In vitro and in vivo photothermally enhanced chemotherapy by single-walled carbon nanohorns as a drug delivery system.JOURNAL OF MATERIALS CHEMISTRY B,2(29),4726-4732. |
| MLA | Chen, Daiqin,et al."In vitro and in vivo photothermally enhanced chemotherapy by single-walled carbon nanohorns as a drug delivery system".JOURNAL OF MATERIALS CHEMISTRY B 2.29(2014):4726-4732. |
入库方式： OAI收割
来源：化学研究所
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