Electrospun Tubular Scaffold with Circumferentially Aligned Nanofibers for Regulating Smooth Muscle Cell Growth
文献类型：期刊论文
| 作者 | Wang, Yanming1; Shi, Haigang1; Qiao, Jing1; Tian, Ye1; Wu, Man1; Zhang, Wei1; Lin, Yuan2; Niu, Zhongwei1; Huang, Yong1 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2014-02-26 |
| 卷号 | 6期号:4页码:2958-2962 |
| 关键词 | Electrospinning Alignment Tubular Scaffold Cell Culture Smooth Muscle Cells Phenotype |
| ISSN号 | 1944-8244 |
| 英文摘要 | Simulation for the smooth muscle layer of blood vessel plays a key role in tubular tissue engineering. However, fabrication of biocompatible tube with defined inner nano/micro-structure remains a challenge. Here, we show that a biocompatible polymer tube from poly(L-lactide) (PLLA) and polydimethylsiloxane (PDMS) can be prepared by using electrospinning technique, with assistance of rotating collector and parallel auxiliary electrode. The tube has circumferentially aligned PLLA fibers in the inner surface for cell growth regulation and has a PDMS coating for better compressive property. MTT assay showed the composite PLLA/PDMS tube was suitable for various cells growth. In vitro smooth muscle cells (SMCs) cultured in the tube showed that the aligned PLLA fibers could induce SMCs' orientation, and different expression of alpha-SMA and OPN genes were observed on the aligned and random PLLA fibers, respectively. The successful fabrication of composite PLLA/PDMS tubular scaffold for regulating smooth muscle cells outgrowth has important implications for tissue-engineered blood vessels. |
| 语种 | 英语 |
| WOS记录号 | WOS:000332144600099 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51789]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Lin, Yuan |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Natl Res Ctr Engn Plast, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yanming,Shi, Haigang,Qiao, Jing,et al. Electrospun Tubular Scaffold with Circumferentially Aligned Nanofibers for Regulating Smooth Muscle Cell Growth[J]. ACS APPLIED MATERIALS & INTERFACES,2014,6(4):2958-2962. |
| APA | Wang, Yanming.,Shi, Haigang.,Qiao, Jing.,Tian, Ye.,Wu, Man.,...&Huang, Yong.(2014).Electrospun Tubular Scaffold with Circumferentially Aligned Nanofibers for Regulating Smooth Muscle Cell Growth.ACS APPLIED MATERIALS & INTERFACES,6(4),2958-2962. |
| MLA | Wang, Yanming,et al."Electrospun Tubular Scaffold with Circumferentially Aligned Nanofibers for Regulating Smooth Muscle Cell Growth".ACS APPLIED MATERIALS & INTERFACES 6.4(2014):2958-2962. |
入库方式： OAI收割
来源：化学研究所
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