Explicit Differentiation of G-Quadruplex/Ligand Interactions: Triplet Excited States as Sensitive Reporters
文献类型：期刊论文
| 作者 | Song, Di; Yang, Wen; Qin, Tingxiao; Wu, Lidan; Liu, Kunhui; Su, Hongmei |
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY LETTERS
 |
| 出版日期 | 2014-07-03 |
| 卷号 | 5期号:13页码:2259-2266 |
| ISSN号 | 1948-7185 |
| DOI | 10.1021/jz501040a |
| 英文摘要 | We report a new transient spectral method utilizing triplet excited state as sensitive reporters to monitor and differentiate the multiplex G-quadruplex/ligand interactions in a single assay, which is a difficult task and usually requires a combination of several techniques. From a systematic study on the interactions of porphyrin (TMPyP4) with each telomeric G-quadruplex: AG(3)(T(2)AG(3))(3), G(2)T(2)G(2)TGTG(2)T(2)G(2), (G(4)T(4)G(4))(2), and (TG(4)T)(4), it is convincingly shown that the ligand triplet decay lifetimes are sensitive to the local bound microenviromnent within G-quadruplexes, from which the coexisting binding modes of end-stacking, intercalation, and sandwich are distinguished and their respective contribution are determined. The complete scenario of mixed interaction modes is thus revealed, shedding light on the past controversial issues. Additional control experiments demonstrate the sensitivity of this triplet reporter method, which can even capture the binding behavior change as the G-quadruplex structures are adjusted by Na+ or K+. |
| 语种 | 英语 |
| WOS记录号 | WOS:000338693200016 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51885]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Su, Hongmei |
| 作者单位 | Chinese Acad Sci, Inst Chem, State Key Lab Mol React Dynam, BNLMS, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Di,Yang, Wen,Qin, Tingxiao,et al. Explicit Differentiation of G-Quadruplex/Ligand Interactions: Triplet Excited States as Sensitive Reporters[J]. JOURNAL OF PHYSICAL CHEMISTRY LETTERS,2014,5(13):2259-2266. |
| APA | Song, Di,Yang, Wen,Qin, Tingxiao,Wu, Lidan,Liu, Kunhui,&Su, Hongmei.(2014).Explicit Differentiation of G-Quadruplex/Ligand Interactions: Triplet Excited States as Sensitive Reporters.JOURNAL OF PHYSICAL CHEMISTRY LETTERS,5(13),2259-2266. |
| MLA | Song, Di,et al."Explicit Differentiation of G-Quadruplex/Ligand Interactions: Triplet Excited States as Sensitive Reporters".JOURNAL OF PHYSICAL CHEMISTRY LETTERS 5.13(2014):2259-2266. |
入库方式： OAI收割
来源：化学研究所
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