Synthesis and biological evaluation of novel (TcN)-Tc-99m-labeled bisnitroimidazole complexes containing monoamine-monoamide dithiol as potential tumor hypoxia markers
文献类型：期刊论文
| 作者 | Mei, Lei; Sun, Wenjing; Chu, Taiwei |
| 刊名 | JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
 |
| 出版日期 | 2014-09-01 |
| 卷号 | 301期号:3页码:831-838 |
| 关键词 | Tumor Hypoxia Radiolabeling Mama Bisnitroimidazole Technetium-nitrido Complex |
| ISSN号 | 0236-5731 |
| DOI | 10.1007/s10967-014-3235-6 |
| 英文摘要 | Tumor hypoxia can decrease the efficacy of clinical therapy due to resistance toward radiation damage and chemotherapy, thus detection of tumor hypoxia by radiolabeled hypoxia markers is important for the control of tumor. Radiopharmaceuticals with two bioreductive groups, such as propylene amine oxime-bisnitroimidazole or monoamine-monoamide dithiol (MAMA) -bisnitroimidazole, have potential to improve hypoxia selectivity. In order to obtain radiopharmaceuticals with better features, we synthesized two novel [(TcN)-Tc-99m](2+) complexes with bisnitroimidazole moieties and MAMA ligand for targeting tumor hypoxia. Their physicochemical characters and biodistribution were also investigated. Both the [(TcN)-Tc-99m](2+) complexes show good stability and hydrophilicity. They show faster clearance from blood and soft tissues, better tumor retention and favorable tumor-to-tissue ratios compared with a control complex without nitroimidazole group. In addition, both of them show more favorable biodistribution patterns than the corresponding [(TcO)-Tc-99m](3+) complexes. These results indicate that the (TcN)-Tc-99m-labeled MAMA-bisnitroimidazole complexes would have potential to image tumor hypoxia in vivo. |
| 语种 | 英语 |
| WOS记录号 | WOS:000340491000022 |
| 出版者 | SPRINGER |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/52027]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chu, Taiwei |
| 作者单位 | Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Radiochem & Radiat Chem Key Lab Fundamental Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mei, Lei,Sun, Wenjing,Chu, Taiwei. Synthesis and biological evaluation of novel (TcN)-Tc-99m-labeled bisnitroimidazole complexes containing monoamine-monoamide dithiol as potential tumor hypoxia markers[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2014,301(3):831-838. |
| APA | Mei, Lei,Sun, Wenjing,&Chu, Taiwei.(2014).Synthesis and biological evaluation of novel (TcN)-Tc-99m-labeled bisnitroimidazole complexes containing monoamine-monoamide dithiol as potential tumor hypoxia markers.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,301(3),831-838. |
| MLA | Mei, Lei,et al."Synthesis and biological evaluation of novel (TcN)-Tc-99m-labeled bisnitroimidazole complexes containing monoamine-monoamide dithiol as potential tumor hypoxia markers".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 301.3(2014):831-838. |
入库方式： OAI收割
来源：化学研究所
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