Translocation of a nanoparticle through a fluidic channel: the role of grafted polymers
文献类型：期刊论文
| 作者 | Su, Jiaye1; Yang, Keda2; Guo, Hongxia1 |
| 刊名 | NANOTECHNOLOGY
 |
| 出版日期 | 2014-05-09 |
| 卷号 | 25期号:18 |
| 关键词 | Nanoparticle Channel Transport |
| ISSN号 | 0957-4484 |
| DOI | 10.1088/0957-4484/25/18/185703 |
| 英文摘要 | The surface properties of nanoparticles (NPs) are key factors for their design and use in biomedicine; however, our understanding of the effect of surface properties on the translocation of NPs through membranes is still rather poor. Herein, we have used molecular dynamics simulations to study the translocation of a polymer-grafted NP through a fluidic channel. We change the length, number, amount of charge and the charge position of grafted polymers. With the increase of polymer length, the NP flux decreases as a whole due to the increase of NP size, where the-NP translocation fails at the smallest polymer length, because of the strong binding of Na+. Surprisingly, the -NP flux exhibits a maximum with the increase of the polymer number or charge amount, which is co-determined by the NP net charge and size. Owing to the NPmembrane adsorption and NP-ion binding, the NP flux decreases with the decrease of charge position. We also analyze the transport of counterions, which depends on both the NP-ion binding and NP dynamics. Finally, we investigate the effect of electric fields for a given NP type. Our results reveal the important role of grafted polymers in the NP translocation and may have implications in the design of highly efficient NP delivery. |
| 语种 | 英语 |
| WOS记录号 | WOS:000334363600009 |
| 出版者 | IOP PUBLISHING LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/52079]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Su, Jiaye |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Joint Lab Polymer Sci & Mat,Beijing Natl Lab Mol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Comp Network Informat Ctr, Supercomp Ctr, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Su, Jiaye,Yang, Keda,Guo, Hongxia. Translocation of a nanoparticle through a fluidic channel: the role of grafted polymers[J]. NANOTECHNOLOGY,2014,25(18). |
| APA | Su, Jiaye,Yang, Keda,&Guo, Hongxia.(2014).Translocation of a nanoparticle through a fluidic channel: the role of grafted polymers.NANOTECHNOLOGY,25(18). |
| MLA | Su, Jiaye,et al."Translocation of a nanoparticle through a fluidic channel: the role of grafted polymers".NANOTECHNOLOGY 25.18(2014). |
入库方式： OAI收割
来源：化学研究所
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