Ratiometric Fluorescent Probe Based on Gold Nanoclusters and Alizarin Red-Boronic Acid for Monitoring Glucose in Brain Microdialysate
文献类型：期刊论文
| 作者 | Wang, Lu-Liang1,2,3; Qiao, Juan1; Liu, Hui-Hui1; Hao, Jie1; Qi, Li1; Zhou, Xiao-Ping2,3; Li, Dan2,3; Nie, Zong-Xiu1; Mao, Lan-Qun1 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2014-10-07 |
| 卷号 | 86期号:19页码:9758-9764 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/ac5023293 |
| 英文摘要 | Glucose monitoring with high sensitivity and accuracy in the cerebrospinal fluid is a challenge for evaluating the role of glucose in the physiological and pathological processes. In this work, a ratiometric fluorescent probe for sensing glucose was developed. In the probe, the gold nanoclusters protected by ovalbumin played the role as the reference of fluorophore and the Alizarin Red S-3-aminophenyl boronic acid immobilized on the poly(N-acryloxysuccinimide) acted as both the response signal and specific recognition unit for sensing glucose. Once the ratiometric fluorescent probe reacted with glucose in the biological system, its fluorescence intensity at 567 nm was quenched, while the fluorescence intensity at 610 nm was essentially unchanged. In addition, the prepared ratiometric fluorescent probe showed higher stability against environmental effects. As a result, the present ratiometric fluorescent probe was successfully used for monitoring of glucose in the rat brain following the cerebral calm/ischemia. |
| 语种 | 英语 |
| WOS记录号 | WOS:000343017100060 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/52113]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Qi, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Shantou Univ, Dept Chem, Shantou 515063, Guangdong, Peoples R China 3.Shantou Univ, Res Inst Biomed & Adv Mat, Shantou 515063, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Lu-Liang,Qiao, Juan,Liu, Hui-Hui,et al. Ratiometric Fluorescent Probe Based on Gold Nanoclusters and Alizarin Red-Boronic Acid for Monitoring Glucose in Brain Microdialysate[J]. ANALYTICAL CHEMISTRY,2014,86(19):9758-9764. |
| APA | Wang, Lu-Liang.,Qiao, Juan.,Liu, Hui-Hui.,Hao, Jie.,Qi, Li.,...&Mao, Lan-Qun.(2014).Ratiometric Fluorescent Probe Based on Gold Nanoclusters and Alizarin Red-Boronic Acid for Monitoring Glucose in Brain Microdialysate.ANALYTICAL CHEMISTRY,86(19),9758-9764. |
| MLA | Wang, Lu-Liang,et al."Ratiometric Fluorescent Probe Based on Gold Nanoclusters and Alizarin Red-Boronic Acid for Monitoring Glucose in Brain Microdialysate".ANALYTICAL CHEMISTRY 86.19(2014):9758-9764. |
入库方式： OAI收割
来源：化学研究所
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