Prevention of local liver cancer recurrence after surgery using multilayered cisplatin-loaded polylactide electrospun nanofibers
文献类型：期刊论文
| 作者 | Zhang, Yan1; Liu, Shi2,3; Wang, Xue4; Zhang, Zhi-yun2,3; Jing, Xia-bin2; Zhang, Zhi-yun; Jing, Xia-bin; Zhang, Ping1; Xie, Zhi-gang2 |
| 刊名 | CHINESE JOURNAL OF POLYMER SCIENCE
 |
| 出版日期 | 2014-08-01 |
| 卷号 | 32期号:8页码:1111-1118 |
| 关键词 | Liver Cancer Local Recurrence Multilayered Nanofibers Cisplatin |
| ISSN号 | 0256-7679 |
| DOI | 10.1007/s10118-014-1491-0 |
| 英文摘要 | In this study a cisplatin-loaded, multilayered polylactide (PLA) electrospun nanofibers, with the structure of two layers of drug-loaded mat being sandwiched by three layers of blank mat, were designed for prolonged cisplatin release at surgical margin to prevent local cancer recurrence following surgical resection in a murine model. In vivo drug release and biodistribution study suggested that the multilayered fibrous mat displayed a slower cisplatin release behavior and a more stable drug rentention in the local tissue within 24 h than that of single-layered fibrous mat. By covering the surgical site with the multilayered fibrous mat following resection of subcutaneous liver cancer in mice, retarded tumor recurrence, prolonged survival time and less systemic toxicity were observed compared with other treatment groups. |
| 语种 | 英语 |
| WOS记录号 | WOS:000338631400016 |
| 出版者 | SPRINGER |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/52191]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, Ping |
| 作者单位 | 1.Jilin Univ, Hosp 1, Changchun 130021, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Jilin Univ, Hlth Improving Dept, China Japan Union Hosp, Changchun 130033, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yan,Liu, Shi,Wang, Xue,et al. Prevention of local liver cancer recurrence after surgery using multilayered cisplatin-loaded polylactide electrospun nanofibers[J]. CHINESE JOURNAL OF POLYMER SCIENCE,2014,32(8):1111-1118. |
| APA | Zhang, Yan.,Liu, Shi.,Wang, Xue.,Zhang, Zhi-yun.,Jing, Xia-bin.,...&Xie, Zhi-gang.(2014).Prevention of local liver cancer recurrence after surgery using multilayered cisplatin-loaded polylactide electrospun nanofibers.CHINESE JOURNAL OF POLYMER SCIENCE,32(8),1111-1118. |
| MLA | Zhang, Yan,et al."Prevention of local liver cancer recurrence after surgery using multilayered cisplatin-loaded polylactide electrospun nanofibers".CHINESE JOURNAL OF POLYMER SCIENCE 32.8(2014):1111-1118. |
入库方式： OAI收割
来源：化学研究所
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