Modified composite microspheres of hydroxyapatite and poly(lactide-co-glycolide) as an injectable scaffold
文献类型：期刊论文
| 作者 | Hu, Xixue1,2; Shen, Hong1; Yang, Fei1; Liang, Xinjie2; Wang, Shenguo1; Wu, Decheng1 |
| 刊名 | APPLIED SURFACE SCIENCE
 |
| 出版日期 | 2014-02-15 |
| 卷号 | 292页码:764-772 |
| 关键词 | Hydroxyapatite Poly(Lactide-co-glycolide) Composite Microspheres Injectable Scaffold Tissue Engineering |
| ISSN号 | 0169-4332 |
| DOI | 10.1016/j.apsusc.2013.12.045 |
| 英文摘要 | The compound of hydroxyapatite-poly( lactide-co-glycolide) (HA-PLGA) was prepared by ionic bond between HA and PLGA. HA-PLGA was more stable than the simple physical blend of hydroxyapatite and poly(lactide-co-glycolide) (HA/PLGA). The surface of HA-PLGA microsphere fabricated by an emulsion-solvent evaporation method was rougher than that of HA/PLGA microspheres. Moreover, surface HA content of HA-PLGA microspheres was more than that of HA/PLGA microspheres. In vitro mouse OCT-1 osteoblast-like cell culture results showed that the HA-PLGA microspheres clearly promoted osteoblast attachment, proliferation and alkaline phosphatase activity. It was considered that surface rich HA component and rough surface of HA-PLGA microsphere enhanced cell growth and differentiation. The good cell affinity of the HA-PLGA microspheres indicated that they could be used as an injectable scaffold for bone tissue engineering. (C) 2013 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000330208500106 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/52309]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Shen, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, BNLMS, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xixue,Shen, Hong,Yang, Fei,et al. Modified composite microspheres of hydroxyapatite and poly(lactide-co-glycolide) as an injectable scaffold[J]. APPLIED SURFACE SCIENCE,2014,292:764-772. |
| APA | Hu, Xixue,Shen, Hong,Yang, Fei,Liang, Xinjie,Wang, Shenguo,&Wu, Decheng.(2014).Modified composite microspheres of hydroxyapatite and poly(lactide-co-glycolide) as an injectable scaffold.APPLIED SURFACE SCIENCE,292,764-772. |
| MLA | Hu, Xixue,et al."Modified composite microspheres of hydroxyapatite and poly(lactide-co-glycolide) as an injectable scaffold".APPLIED SURFACE SCIENCE 292(2014):764-772. |
入库方式： OAI收割
来源：化学研究所
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