Strategies to overcome the barrier: use of nanoparticles as carriers and modulators of barrier properties
文献类型：期刊论文
| 作者 | Rempe, Ralf1; Cramer, Sandra1; Qiao, Ruirui2; Galla, Hans-Joachim1 |
| 刊名 | CELL AND TISSUE RESEARCH
 |
| 出版日期 | 2014-03-01 |
| 卷号 | 355期号:3页码:717-726 |
| 关键词 | Blood-brain Barrier Nanoparticles Endocytosis Tight Junction Lactoferrin |
| ISSN号 | 0302-766X |
| DOI | 10.1007/s00441-014-1819-7 |
| 英文摘要 | The blood-brain barrier (BBB) protects the brain from toxic substances within the bloodstream and keeps the brain's homeostasis stable. On the other hand, it also represents the main obstacle in the treatment of many CNS diseases. Among different techniques, nanoparticles have emerged as promising tools to enhance brain drug delivery of therapeutic molecules. For successful drug delivery, nanoparticles may either modulate BBB integrity or exploit transport systems present on the endothelium. In this review, we present two different nanoparticles to enhance brain drug delivery. Poly(butyl cyanoacrylate) nanoparticles were shown to induce a reversible disruption of the BBB in vitro which may be exploited by simultaneous injection of the drug in question. By coating the poly(butyl cyanoacrylate) nanoparticles with, e.g., ApoE, it is also possible to circumvent the BBB via the LDL-receptor. Another example of the use of receptor-mediated endocytosis to enhance brain uptake of nanoparticles are poly(ethylene glycol)-coated Fe3O4 nanoparticles which are covalently attached to lactoferrin. These nanoparticles have been shown to facilitate the transport via the lactoferrin receptor, and so could then be used for magnetic resonance imaging. |
| 语种 | 英语 |
| WOS记录号 | WOS:000334173000019 |
| 出版者 | SPRINGER |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/52327]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Galla, Hans-Joachim |
| 作者单位 | 1.Univ Munster, Dept Biochem, D-48149 Munster, Germany 2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Rempe, Ralf,Cramer, Sandra,Qiao, Ruirui,et al. Strategies to overcome the barrier: use of nanoparticles as carriers and modulators of barrier properties[J]. CELL AND TISSUE RESEARCH,2014,355(3):717-726. |
| APA | Rempe, Ralf,Cramer, Sandra,Qiao, Ruirui,&Galla, Hans-Joachim.(2014).Strategies to overcome the barrier: use of nanoparticles as carriers and modulators of barrier properties.CELL AND TISSUE RESEARCH,355(3),717-726. |
| MLA | Rempe, Ralf,et al."Strategies to overcome the barrier: use of nanoparticles as carriers and modulators of barrier properties".CELL AND TISSUE RESEARCH 355.3(2014):717-726. |
入库方式： OAI收割
来源：化学研究所
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